Nature Microbiology paper on application of eNTRy rules


Complex Compounds from Pleuromutilin Yields a Pro-Ferroptotic Agent


Nature paper on novel broad-spectrum antibiotics


PAC-1 shows efficacy in a dog trial

Complex compounds from Sinomenine

Complex compounds from Sinomenine

Pets to People research theme established at UIUC IGB

Ring distortion from pleuromutilin

Apoptotic induction with unparalleled speed

PAC-1 clinical trial in human cancer patients

Synthesis of dimeric ADP-ribose and x-ray structure with target

Welcome to the Hergenrother Lab!

With a guiding theme of using chemistry and small-molecules to identify, explore, and define novel targets for the treatment of disease, we aspire to make an impact in both chemistry and biology. We are both chemists and biologists, using the scientific techniques necessary to solve complex disease-driven questions.

In the Hergenrother lab, we are fully committed to fostering a culture of diversity, inclusion, and equity in our lab and department. Our group welcomes all people with talent of all racial, cultural, and socioeconomic backgrounds, sexual orientations, and gender expressions to join us in our pursuit of scientific discovery. We pledge to be supportive of all individuals and maintain a collaborative and inclusive environment

Hergenrother Lab News:



Read Young Innovator profile on Dr. Diana Ranoa, describing her pivotal role in developing the UIUC saliva test for COVID-19.

A Phase 1B/2 clinical trial of PAC-1 for patients with metastatic uveal melanoma is now enrolling

A compound for breast cancer discovered and developed in the Hergenrother and Shapiro labs has been licensed to Bayer.

Congratulations to graduate student Matthew Boudreau who has been awarded a prestigious F99/K00 Award from the NCI!

Congratulations to Dr. Steven Motika for being awarded a postdoctoral fellowship from the NIH!

Congratulations to Matthew Boudreau for being awarded a predoctoral fellowship from the Medicinal Chemistry division of the ACS!

See story on Pretzel, a pet dog with glioma successfully treated with PAC-1.

eNTRyway, our web app for predicting compound accumulation in Gram-negative bacteria, is live!

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