HERGENROTHER LAB
Using small molecules to define new targets for the treatment of disease
DISSERTATIONS
2020
Dr. Sarah Perlmutter -- “The Influence of Positively Charged Nitrogen Species on Compound Accumulation and Activity in Gram-Negative Bacteria”
Dr. Riley L. Svec -- “Development of Imidazotetrazines for the Treatment of Glioblastoma and as Synthetic Precursors to Diazo Species”
2019
Dr. Alfredo Garcia -- “Ring Distortion of the Alkaloid Sinomenine and Novel Prodrug Approaches to Broad-Spectrum Antibiotics”
2018
Dr. Evi Llablani -- “Discovery and Biological Evaluation of Ferroptocide”
Dr. Bryon Drown -- “Chemical Approaches to Understanding Small-Molecule Accumulation in Bacteria and Poly(ADP-Ribosyl)ation”
2017
Dr. Jessie Peh -- “Procaspase-3 Activation as a Strategy to Overcome Resistance to Targeted Anticancer Therapies”
Dr. Michelle F. Richter -- “Development of Predictive Guidelines for Compound Accumulation in Gram-Negative Bacteria”
2016
Dr. Michael J. Lambrecht -- “The Chemical and Enzymatic Synthesis of Poly(ADP-Ribose)"
Dr. Rachel C. Botham -- “Development of PAC-1 as a Privileged Agent for Combination Chemotherapy”
2015
Dr. Robert W. Hicklin -- “Chemical Diversification of the Natural Products Quinine, Abietic Acid, and Pleuromutilin by Ring Distortion”
Dr. Elizabeth I. Parkinson -- "Deoxynyboquinoes as NQO1-Targeted Anticancer Compounds and Deoxynybomycins as Potent and Selective Antibiotics"
Dr. Howard S. Roth -- "Improving the Process Syntheis, Potency, and Pharmacokinetics of the Anticancer Compound PAC-1"
2014
Dr. Claire E. Knezevic -- "Development of Poly(ADP-Ribose) Glycohydrolase Inhibitors and Tetracyclic Indoles as Anticancer Compounds"
Dr. Emilia C. Calvaresi -- "Small Molecule Inhibitors of Lactate Dehydrogenase A as an Anticancer Strategy”
2013
Dr. Julia J. Williams -- "Suitability of RelBE and MazEF Toxin-Antitoxin Systems as Antibacterial Targets"
Dr. Karen Morrison -- "Chemical Diversification and Anticancer Activity of Natural Products"
2012
Dr. Timothy Alan Flood, Jr. -- "Advances in High-Throughput Screening: Better Compounds, Novel Targets, Enhanced Sensors"
2011
Dr. Joseph Bair -- "The Development of Deoxynyboquinone as a Personalized Anticancer Compound"
Dr. Quinn Peterson -- "Small Molecule Activators of Procaspase-3 as an Anticancer Strategy"
Dr. Rahul Palchaudhuri -- "Development and Mechanistic Characterization of Novel Small Molecules as Cancer Therapeutics"
Dr. Diana West -- "The Discovery and Characterization of Anticancer Procaspase-Activating Compounds"
Dr. Kristin Finch -- "The Discovery of Small Molecule Inhibitors of Poly(ADP-Ribose) Mediated Cell Death"
Dr. Nora Wang -- "The Identification and Characterization of Novel Antibacterial Compounds via Target-Based and Whole Cell Screening Approaches"
2010
Dr. Elizabeth Moritz Halvorsen-- "The Prevalence of Toxin-Antitoxin Systems and Their Tractability as Novel Antimicrobial Targets"
Dr. Mirth T. Hoyt -- "The Anticancer Mode of Action of the Quinone Natural Product Cribostatin 6"
Dr. James T. Heeres -- "High-Throughput Detection of Protein—Protein and Protein—DNA Interactions Via Photonic Crystal Biosensors: Applications to Apoptosis Inducing Factor"
2009
Dr. Todd Meyer -- "Selective Targeting of RNA with Small Molecules: Design and Synthesis of Ligands for Selective Binding to RNA Bulges and Hairpin Loops"
Dr. Benjamin Leslie -- "Small Molecule Modulation of the Cell Cycle: Discovery of Anticancer Compounds that Induce G1- and M-Phase Cell Cycle Arrest and Characterization of Their Modes of Action"
2008
Dr. Christina Thompson -- "The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs"
Dr. Robin S. Dothager -- "Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds that Induce G1 Cell Cycle Arrest"
Dr. Amanda C. Nottbohm -- "Chemical Tools to Monitor and Inhibit Poly(ADP-Ribosyl)ation"
2007
Dr. David Goode -- "Small Molecule Modulation of Caspase Enzymatic Activity"
Dr. Jason R. Thomas -- "Toward the Therapies of Tomorrow: Selective RNA-Binding Small Molecules and Cytoprotective Strategies for ROS-Mediated Disease States"
2006
Dr. Dinty J. Musk -- "Discovery and Characterization of Small Molecule Inhibitors of Biofilm Formation inPseudomonas aeruginosa"
Dr. Karson S. Putt -- "The Modulation of Life and Death: Small Molecule Activators and Inhibitors of Necrotic and Apoptotic Pathways"
Dr. Vitaliy Nesterenko -- "Synthesis of Biologically Active Cytoprotective and Anticancer Small Molecules"