DISSERTATIONS

2019

Dr. Alfredo Garcia -- “Ring Distortion of the Alkaloid Sinomenine and Novel Prodrug Approaches to Broad-Spectrum Antibiotics 

2018

Dr. Evi Llablani -- Discovery and Biological Evaluation of Ferroptocide”

Dr. Bryon Drown -- “Chemical Approaches to Understanding Small-Molecule Accumulation in Bacteria and Poly(ADP-Ribosyl)ation”

2017

Dr. Jessie Peh -- “Procaspase-3 Activation as a Strategy to Overcome Resistance to Targeted Anticancer Therapies”

 

Dr. Michelle F. Richter -- “Development of Predictive Guidelines for Compound Accumulation in Gram-Negative Bacteria”

2016

Dr. Michael J. Lambrecht -- “The Chemical and Enzymatic Synthesis of Poly(ADP-Ribose)"

Dr. Rachel C. Botham -- “Development of PAC-1 as a Privileged Agent for Combination Chemotherapy”

2015

 

Dr. Robert W. Hicklin -- “Chemical Diversification of the Natural Products Quinine, Abietic Acid, and Pleuromutilin by Ring Distortion”

 

Dr. Elizabeth I. Parkinson -- "Deoxynyboquinoes as NQO1-Targeted Anticancer Compounds and Deoxynybomycins as Potent and Selective Antibiotics"

 

Dr. Howard S. Roth -- "Improving the Process Syntheis, Potency, and Pharmacokinetics of the Anticancer Compound PAC-1"

 

2014

 

Dr. Claire E. Knezevic -- "Development of Poly(ADP-Ribose) Glycohydrolase Inhibitors and Tetracyclic Indoles as Anticancer Compounds"

 

Dr. Emilia C. Calvaresi -- "Small Molecule Inhibitors of Lactate Dehydrogenase A as an Anticancer Strategy”

 

2013

 

Dr. Julia J. Williams -- "Suitability of RelBE and MazEF Toxin-Antitoxin Systems as Antibacterial Targets"
 

Dr. Karen Morrison -- "Chemical Diversification and Anticancer Activity of Natural Products"

 

2012

 

Dr. Timothy Alan Flood, Jr. -- "Advances in High-Throughput Screening: Better Compounds, Novel Targets, Enhanced Sensors"

 

2011

 

Dr. Joseph Bair -- "The Development of Deoxynyboquinone as a Personalized Anticancer Compound"

 

Dr. Quinn Peterson -- "Small Molecule Activators of Procaspase-3 as an Anticancer Strategy"

 

Dr. Rahul Palchaudhuri -- "Development and Mechanistic Characterization of Novel Small Molecules as Cancer Therapeutics"

 

Dr. Diana West -- "The Discovery and Characterization of Anticancer Procaspase-Activating Compounds"

 

Dr. Kristin Finch -- "The Discovery of Small Molecule Inhibitors of Poly(ADP-Ribose) Mediated Cell Death"

 

Dr. Nora Wang -- "The Identification and Characterization of Novel Antibacterial Compounds via Target-Based and Whole Cell Screening Approaches"

 

2010

 

Dr. Elizabeth Moritz Halvorsen-- "The Prevalence of Toxin-Antitoxin Systems and Their Tractability as Novel Antimicrobial Targets"

 

Dr. Mirth T. Hoyt -- "The Anticancer Mode of Action of the Quinone Natural Product Cribostatin 6"

 

Dr. James T. Heeres -- "High-Throughput Detection of Protein—Protein and Protein—DNA Interactions Via Photonic Crystal Biosensors: Applications to Apoptosis Inducing Factor"

 

2009

 

Dr. Todd Meyer -- "Selective Targeting of RNA with Small Molecules: Design and Synthesis of Ligands for Selective Binding to RNA Bulges and Hairpin Loops"

 

Dr. Benjamin Leslie -- "Small Molecule Modulation of the Cell Cycle: Discovery of Anticancer Compounds that Induce G1- and M-Phase Cell Cycle Arrest and Characterization of Their Modes of Action"

 

2008

 

Dr. Christina Thompson -- "The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs"

 

Dr. Robin S. Dothager -- "Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds that Induce G1 Cell Cycle Arrest"

 

Dr. Amanda C. Nottbohm -- "Chemical Tools to Monitor and Inhibit Poly(ADP-Ribosyl)ation"

 

2007

 

Dr. David Goode -- "Small Molecule Modulation of Caspase Enzymatic Activity"

 

Dr. Jason R. Thomas -- "Toward the Therapies of Tomorrow: Selective RNA-Binding Small Molecules and Cytoprotective Strategies for ROS-Mediated Disease States"

 

2006

 

Dr. Dinty J. Musk -- "Discovery and Characterization of Small Molecule Inhibitors of Biofilm Formation inPseudomonas aeruginosa"

 

Dr. Karson S. Putt -- "The Modulation of Life and Death: Small Molecule Activators and Inhibitors of Necrotic and Apoptotic Pathways"

 

Dr. Vitaliy Nesterenko -- "Synthesis of Biologically Active Cytoprotective and Anticancer Small Molecules"

Professor Paul J. Hergenrother

hergenro@illinois.edu

261 Roger Adams Lab

600 S. Mathews Avenue

Urbana, IL 61802

The Chemistry Department at the University of Illinois

Copyright © 2014 The Hergenrother Group

Julie Bass

Administrative Assistant

jlbass2@illinois.edu

245 Roger Adams Lab

#PJHteam