Dr. Sarah Perlmutter -- “The Influence of Positively Charged Nitrogen Species on Compound Accumulation and Activity in Gram-Negative Bacteria”

Dr. Riley L. Svec -- “Development of Imidazotetrazines for the Treatment of Glioblastoma and as Synthetic Precursors to Diazo Species”


Dr. Alfredo Garcia -- “Ring Distortion of the Alkaloid Sinomenine and Novel Prodrug Approaches to Broad-Spectrum Antibiotics 


Dr. Evi Llablani -- Discovery and Biological Evaluation of Ferroptocide”

Dr. Bryon Drown -- “Chemical Approaches to Understanding Small-Molecule Accumulation in Bacteria and Poly(ADP-Ribosyl)ation”


Dr. Jessie Peh -- “Procaspase-3 Activation as a Strategy to Overcome Resistance to Targeted Anticancer Therapies”


Dr. Michelle F. Richter -- “Development of Predictive Guidelines for Compound Accumulation in Gram-Negative Bacteria”


Dr. Michael J. Lambrecht -- “The Chemical and Enzymatic Synthesis of Poly(ADP-Ribose)"

Dr. Rachel C. Botham -- “Development of PAC-1 as a Privileged Agent for Combination Chemotherapy”



Dr. Robert W. Hicklin -- “Chemical Diversification of the Natural Products Quinine, Abietic Acid, and Pleuromutilin by Ring Distortion”


Dr. Elizabeth I. Parkinson -- "Deoxynyboquinoes as NQO1-Targeted Anticancer Compounds and Deoxynybomycins as Potent and Selective Antibiotics"


Dr. Howard S. Roth -- "Improving the Process Syntheis, Potency, and Pharmacokinetics of the Anticancer Compound PAC-1"




Dr. Claire E. Knezevic -- "Development of Poly(ADP-Ribose) Glycohydrolase Inhibitors and Tetracyclic Indoles as Anticancer Compounds"


Dr. Emilia C. Calvaresi -- "Small Molecule Inhibitors of Lactate Dehydrogenase A as an Anticancer Strategy”




Dr. Julia J. Williams -- "Suitability of RelBE and MazEF Toxin-Antitoxin Systems as Antibacterial Targets"

Dr. Karen Morrison -- "Chemical Diversification and Anticancer Activity of Natural Products"




Dr. Timothy Alan Flood, Jr. -- "Advances in High-Throughput Screening: Better Compounds, Novel Targets, Enhanced Sensors"




Dr. Joseph Bair -- "The Development of Deoxynyboquinone as a Personalized Anticancer Compound"


Dr. Quinn Peterson -- "Small Molecule Activators of Procaspase-3 as an Anticancer Strategy"


Dr. Rahul Palchaudhuri -- "Development and Mechanistic Characterization of Novel Small Molecules as Cancer Therapeutics"


Dr. Diana West -- "The Discovery and Characterization of Anticancer Procaspase-Activating Compounds"


Dr. Kristin Finch -- "The Discovery of Small Molecule Inhibitors of Poly(ADP-Ribose) Mediated Cell Death"


Dr. Nora Wang -- "The Identification and Characterization of Novel Antibacterial Compounds via Target-Based and Whole Cell Screening Approaches"




Dr. Elizabeth Moritz Halvorsen-- "The Prevalence of Toxin-Antitoxin Systems and Their Tractability as Novel Antimicrobial Targets"


Dr. Mirth T. Hoyt -- "The Anticancer Mode of Action of the Quinone Natural Product Cribostatin 6"


Dr. James T. Heeres -- "High-Throughput Detection of Protein—Protein and Protein—DNA Interactions Via Photonic Crystal Biosensors: Applications to Apoptosis Inducing Factor"




Dr. Todd Meyer -- "Selective Targeting of RNA with Small Molecules: Design and Synthesis of Ligands for Selective Binding to RNA Bulges and Hairpin Loops"


Dr. Benjamin Leslie -- "Small Molecule Modulation of the Cell Cycle: Discovery of Anticancer Compounds that Induce G1- and M-Phase Cell Cycle Arrest and Characterization of Their Modes of Action"




Dr. Christina Thompson -- "The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs"


Dr. Robin S. Dothager -- "Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds that Induce G1 Cell Cycle Arrest"


Dr. Amanda C. Nottbohm -- "Chemical Tools to Monitor and Inhibit Poly(ADP-Ribosyl)ation"




Dr. David Goode -- "Small Molecule Modulation of Caspase Enzymatic Activity"


Dr. Jason R. Thomas -- "Toward the Therapies of Tomorrow: Selective RNA-Binding Small Molecules and Cytoprotective Strategies for ROS-Mediated Disease States"




Dr. Dinty J. Musk -- "Discovery and Characterization of Small Molecule Inhibitors of Biofilm Formation inPseudomonas aeruginosa"


Dr. Karson S. Putt -- "The Modulation of Life and Death: Small Molecule Activators and Inhibitors of Necrotic and Apoptotic Pathways"


Dr. Vitaliy Nesterenko -- "Synthesis of Biologically Active Cytoprotective and Anticancer Small Molecules"

Professor Paul J. Hergenrother


261 Roger Adams Lab

600 S. Mathews Avenue

Urbana, IL 61802

The Chemistry Department at the University of Illinois

Copyright © 2014 The Hergenrother Group

Kate Neef

Administrative Assistant


A131 Chemical and Life Sciences Laboratory