Dr. Parker joined the Hergenrother lab in February 2017 after receiving her Ph.D. in Chemistry at Baylor University. Her graduate studies in the laboratory of Prof. Kevin G. Pinney focused on the design and synthesis of small-molecule, thiosemicarbazone based inhibitors of cathepsin L as potential anti-metastatic agents.



Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L

Parker, E. N.; Odutola, S. O.; Wang, Y.; Strecker, T. E.; Mukherjee, R.; Shi, Z.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.  

Bioorg. Med. Chem. Lett. 201727, 1304-1310.


Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L

Parker, E. N.; Song, J.; Kumar, G. D. K.; Odutola, S. O.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Strecker, T. E.; Barnes, A. L.; Sudhan, D. R.; Wittenborn, T. R.; Siemann, D. W.; Horsman, M. R.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.

Bioorg. Med. Chem. 201521, 6974-6992.


Initial evaluation of the antitumor activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L

Chavarria, G. E; Horsman, M. R.; Arispe, W. M.; Kumar, G. D. K., Chen. S.-E.; Strecker, T. E.; Parker, E. N.; Chaplin, D. J.; Pinney, K. G.; Trawick, M. L.

Eur. J. Med. Chem201258, 568-572.


A practical and highly efficient hydroacylation reaction of azodicarboxylates with aldehydes in water

Zhang, Q.*; Parker, E.*; Headley, A. D.; Ni, B.

Synlett 201016, 2453-2456. *equal authorship


Design and Synthesis of Bistereogenic Chiral Ionic Liquids and Their Use as Solvents for Asymmetric Baylis-Hillman Reactions

Garre, S.; Parker, E.; Ni, B.; Headley, A. D.

Org. Biomol. Chem. 2008, 6, 3041-3043.

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Professor Paul J. Hergenrother


261 Roger Adams Lab

600 S. Mathews Avenue

Urbana, IL 61802

The Chemistry Department at the University of Illinois

Copyright © 2014 The Hergenrother Group

Kate Neef

Administrative Assistant


A131 Chemical and Life Sciences Laboratory