DR. HYANG YEON LEE

Hyang Yeon received her Ph.D. in chemical biology from the laboratory of professor Seung Bum Park at Seoul National University in Korea and joined the Hergenrother lab in February 2012 as a National Research Foundation of Korea Postdoctoral associate.

 

In the Hergenrother laboratory, Dr. Lee has been part of the team that developed and evaluated N-hydroxyindoles(NHI) as novel lactate dehydrogenase inhibitors and potent anticancer agents.

Publications:

 

Reactive Oxygen Species Synergize to Potently and Selectively Induce Cancer Cell Death

Lee, H.-Y.; Parkinson, E. I.; Granchi, C.; Paterni, I.; Panigrahy, D.; Seth, P.; Minutolo, F.; Hergenrother, P. J.

ACS Chem. Biol. 2017, 12, 1416-1424.

 

Salicylketoximes that target Glucose Transporter 1 restrict energy supply to lung cancer cells

Granchi, C.; Qian, Y.; Lee, H. Y.; Paterni, I.; Pasero, C.; Legre, J.; Carlson, K. E.; Tuccinardi, T.; Chen, X.; Katzenellebogen, J. A.; Hergenrother, P. J.; Minutolo, F.

ChemMedChem 2015, 10, 1892-1900.

 

Deoxynybomycins inhibit mutant DNA Gyrase and rescue mice infected with fluoroquinolone-resistant bacteria

Parkinson, E. I.; Bair, J. S.; Nakamura, B.; Lee, H. Y.; Kuttab, H. I.; Southgate, E. H.; Lezmi, S.; Lau, G. W.; Hergenrother, P. J.

Nature Comm. 2015, 6, 6947.

 

Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor

Calvaresi, E. C.; Granchi, C.; Tuccinardi, T.; Bussolo, V. D.; Huigens III, R. W.; Lee, H. Y.; Palchaudhuri, R.; Macchia, M.; Martinelli, A.; Minutolo, F.; Hergenrother, P. J. 

ChemBioChem 2013, 14,  2263-2267.

 

Family-Selective detection of antibiotics using antibody-functionalized carbon nanotube sensors

Kim, B.; Lim, D.; Jin, H. J.; Lee, H. Y.; Namgung, S.; Ko, Y.; Park, S. B.; Hong, S.

Sensors & Actuators B: Chemical 2012, 166-167, 193-199.

 

Pharmacophore-based strategy for the development of general and specific scFv biosensors for abused antibiotics 

Cha, M. Y.; Lee, H. Y.; Ko, Y.; Shim, H.; Park, S. B. 

Bioconjugate Chem. 2011, 22 , 88–94.

 

Development of fluorescent glucose bioprobes and their application on real-time and quantitative monitoring of glucose uptake in live cells.

Lee, H. Y.; Lee, J. J.; Park, J.; Park, S. B.

Chem. Eur. J. 2011, 17, 143–150.

 

Surface modification for small molecule microarray and its application for the discovery of tyrosinase inhibitor

Lee, H. Y.; Park, S. B.

Mol. Biosyst. 2011, 7, 304–310.

 

Anti-diabetic and anti-obesity effects of Ampkinone, a novel small molecule activator of AMP-activated protein kinase (AMPK)

Oh, S.; Kim, S. J.; Hwang, J. H.; Lee, H. Y.; Ryu, M. J.; Park, J.; Kim, S. J.; Jo, Y. S.; Kim, Y. K.; Lee, C. H.; Kweon, K. R.; Shong, M.; Park, S. B.

J. Med. Chem. 2010, 53, 7405–7413.

 

Crystal structure of Tpa1 from saccharomyces cerevisiae, a component of the messenger ribonucleoprotein complex

Kim, H. S.; Kim, H. L.; Kim, K. H.; Kim, D. J.; Lee, S. J.; Yoon, J. Y.; Yoon, H. J.; Lee, H. Y.; Park, S. B.; Kim, S.-J.; Lee, J. Y.; Suh, S. W.

Nucleic Acids Research 2010, 38, 2099–2110.

 

A Two-Photon tracer for glucose uptake

Tian, Y. S.; Lee. H. Y.; Lim, C. S.; Park, J.; Kim, H. M.; Shin, Y. N.; Kim, E. S.; Jeon, H. J.; Park, S. B.; Cho, B. R.

Angew. Chem. Int. Ed. 2009, 48, 8027–8031.

 

Enhanced efficacy of 7-hydroxy-3-methoxycadalene via glycosylation in in vivo xenograft study

Lee, H. Y.; Kwon, J.-T.; Koh, M.; Cho, M.-H.; Park, S. B.

Bioorg. Med. Chem. Lett. 2007, 17, 6335–6339.

 

A practical procedure for producing silver nanocoated fabric and its antibacterial evaluation for biomedical applications

Lee, H. Y.; Park, H. K.; Lee, Y. M.; Kim, K.; Park, S. B.

Chem. Commun. 2007, 2959–2961.

 

Development of novel Cy3-labeled glucose bioprobe and its application in bioimaging and screening for anticancer agents 

Lee, H. Y.; Park, J.; Cho, M.-H.; Park, S. B.

Angew. Chem. Int. Ed. 2007, 46, 2018-2022.

 

Quantitative evaluation of HiCore resin for the nonspecific binding of proteins by on-bead colorimetric assay

Kim, D.-H.; Lee, H. Y.; Kim, H.; Kim, H.; Lee, Y.-S.; Park, S. B.

J. Comb. Chem. 2006, 8, 280–285.

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Professor Paul J. Hergenrother

hergenro@illinois.edu

261 Roger Adams Lab

600 S. Mathews Avenue

Urbana, IL 61802

The Chemistry Department at the University of Illinois

Copyright © 2014 The Hergenrother Group

Kate Neef

Administrative Assistant

kneef1@illinois.edu

245 Roger Adams Lab

#PJHteam