DR. MYUNG RYUL LEE

Myung Ryul received his Ph.D. in chemical biology from the laboratory of professor Injae Shin at Yonsei University in Korea. He also worked in the laboratories of Prof. Sam Gellman and Prof. Sean Palecek at University of Wisconsin at Madison. He joined the Hergenrother lab in May 2018. His work is focused on the design and synthesis of novel broad-spectrum antibacterials by conversion of Gram-positive only antibiotics.

Publications:

 

Incorporation of b-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2

Lee, M.-R.; Raman, N.; Gellman, S. H.; Lynn, D. M.; Palecek, S. P. 

ACS Chem. Biol. 2017,12, 2975-2780.

Antifungal activity of a β-peptide in synthetic urine media: Toward materials-based approaches to reducing catheter-associated urinary tract fungal infections

Raman, N.; Lee, M.-R.; Rodriguez Lopez, A. d. L.; Palecek, S. P.; Lynn, D. M. 

Acta Biomater. 201643, 240-250.

Incorporation of β-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2

Lee, M.-R.; Raman, N.; Gellman, S. H.; Lynn, D. M.; Palecek, S. P. 

ACS Chem. Biol. 2017,12(12), 2975-2980.

 

Antifungal activity of a β-peptide in synthetic urine media: Toward materials-based approaches to reducing catheter-associated urinary tract fungal infections

Raman, N.; Lee, M.-R.; Rodriguez Lopez, A. d. L.; Palecek, S. P.; Lynn, D. M. 

Acta Biomater. 201643, 240-250.

 

Hydrophobicity of antifungal β-peptides is associated with their cytotoxic effect on in vitro human colon Caco-2 and liver HepG2 cells

Mora-Navarro, C.; Mendez-Vega, J.; Caraballo-Leon, J.; Lee, M.-R.; Palecek, S.; Torres-Lugo, M.; Ortiz-Bermudez, P. 

PLoS One 2016,11(3), e0149271/0149271-e0149271/0149218.

 

Intraluminal Release of an Antifungal β-Peptide Enhances the Antifungal and Anti-Biofilm Activities of Multilayer-Coated Catheters in a Rat Model of Venous Catheter Infection

Raman, N.; Marchillo, K.; Lee, M.-R.; Rodriguez Lopez, A. d. L.; Andes, D. R.; Palecek, S. P.; Lynn, D. M. 

ACS Biomater.Sci. Eng. 2016, 2(1), 112-121.

 

Antifungal activity of 14-helical β-peptides against planktonic cells and biofilms of Candida Species

Raman, N.; Lee, M.-R.; Lynn, D. M.; Palecek, S. P. 

Pharmaceuticals 20158(3), 483-503.

 

Polymer multilayers loaded with antifungal β-peptides kill planktonic Candida albicans and reduce formation of fungal biofilms on the surfaces of flexible catheter tubes

Raman, N.; Lee, M.-R.; Palecek, S. P.; Lynn, D. M. 

J. Controlled Release 2014,191, 54-62.

 

Hydrophobicity and helicity regulate the antifungal activity of 14-helical β-peptides

Lee, M.-R.; Raman, N.; Gellman, S. H.; Lynn, D. M.; Palecek, S. P. 

ACS Chem. Biol. 2014,9(7), 1613-1621.

 

Sheet-Like Assemblies of Charged Amphiphilic α/β-Peptides at the Air-Water Interface

Segman-Magidovich, S.; Lee, M.-R.; Vaiser, V.; Struth, B.; Gellman, S. H.; Rapaport, H. 

Chem. - Eur. J. 2011,17(52), 14857-14866, S14857/14851-S14857/14856.

 

Highly Stable Pleated-Sheet Secondary Structure in Assemblies of Amphiphilic α/β-Peptides at the Air-Water Interface

Segman, S.; Lee, M.-R.; Vaiser, V.; Gellman, S. H.; Rapaport, H. 

Angew. Chem., Int. Ed. 201049(4), 716-719, S716/711-S716/713.

 

Nylon-3 Copolymers that Generate Cell-Adhesive Surfaces Identified by Library Screening

Lee, M.-R.; Stahl, S. S.; Gellman, S. H.; Masters, K. S. 

J. Am. Chem. Soc. 2009,131(46), 16779-16789.

 

Construction of Carbohydrate Microarrays by Using One-Step, Direct Immobilizations of Diverse Unmodified Glycans on Solid Surfaces

Park, S.; Lee, M.-R.; Shin, I.

Bioconjugate Chem. 200920(1), 155-162.

 

Synthesis of β-Lactams Bearing Functionalized Side Chains from a Readily Available Precursor

Lee, M.-R.; Stahl, S. S.; Gellman, S. H. 

Org. Lett. 2008,10(22), 5317-5319.

 

Carbohydrate microarrays as powerful tools in studies of carbohydrate-mediated biological processes

Park, S.; Lee, M.-R.; Shin, I.

Chem. Commun. (Cambridge, U. K.) 2008,(37),4389-4399.

 

An apoptosis-inducing small molecule that binds to heat shock protein 70

Williams, D. R.; Ko, S.-K.; Park, S.; Lee, M.-R.; Shin, I. 

Angew. Chem., Int. Ed. 200847(39),7466-7469.

 

Chemical tools for functional studies of glycans

Park, S.; Lee, M.-R.; Shin, I.

Chem. Soc. Rev. 2008,37(8), 1579-1591.

 

Fluorescent high-throughput screening of chemical inducers of neuronal differentiation in skeletal muscle cells

Williams, D. R.; Kim, G.-H.; Lee, M.-R.; Shin, I. 

Nat. Protoc. 20083(5), 835-839.

 

Fabrication of carbohydrate chips and their use to probe protein-carbohydrate interactions

Park, S.; Lee, M.-R.; Shin, I.

Nat. Protoc. 20072(11), 2747-2758.

 

Synthetic Small Molecules that Induce Neurogenesis in Skeletal Muscle

Williams, D. R.; Lee, M.-R.; Song, Y.-A.; Ko, S.-K.; Kim, G.-H.; Shin, I. 

J. Am. Chem. Soc. 2007,129(30),9258-9259.

 

Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in β-peptides

Lee, M.-R.; Raguse, T. L.; Schinnerl, M.; Pomerantz, W. C.; Wang, X.; Wipf, P.; Gellman, S. H. 

Org. Lett. 20079(9),1801-1804.

 

Protein microarrays to study carbohydrate-recognition events

Lee, M.-R.; Park, S.; Shin, I.

Bioorg. Med. Chem. Lett. 2006,16(19), 5132-5135.

 

Efficient Solid-Phase Synthesis of Trifunctional Probes and Their Application to the Detection of Carbohydrate-Binding Proteins

Lee, M.-R.; Jung, D.-W.; Williams, D.; Shin, I. 

Org. Lett. 2005,7(24), 5477-5480.

 

Facile Preparation of Carbohydrate Microarrays by Site-Specific, Covalent Immobilization of Unmodified Carbohydrates on Hydrazide-Coated Glass Slides

Lee, M.-R.; Shin, I. 

Org. Lett. 2005,7(19), 4269-4272.

 

Fabrication of chemical microarrays by efficient immobilization of hydrazide-linked substances on epoxide-coated glass surfaces

Lee, M.-R.; Shin, I. 

Angew. Chem., Int. Ed. 2005,44(19), 2881-2884.

 

Carbohydrate microarrays: An advanced technology for functional studies of glycans

Shin, I.; Park, S.; Lee, M.-R.

Chem. - Eur. J. 2005,11(10), 2894-2901.

 

Carbohydrate chips for studying high-throughput carbohydrate-protein interactions

Park, S.; Lee, M.-R.; Pyo, S.-J.; Shin, I. 

J. Am. Chem. Soc. 2004,126(15), 4812-4819.

 

Targeted enzyme-responsive drug carriers: Studies on the delivery of a combination of drugs

Lee, M.-R.; Baek, K.-H.; Jin, H. J.; Jung, Y.-G.; Shin, I. 

Angew. Chem., Int. Ed. 2004,43(13),1675-1678.

 

NMR studies on turn mimetic analogs derived from melanocyte-stimulating hormones

Cho, M.-K.; Kim, S.-S.; Lee, M.-R.; Shin, J.; Lee, J.; Lim, S.-K.; Baik, J.-H.; Yoon, C.-J.; Shin, I.; Lee, W. 

J. Biochem. Mol. Biol. 2003,36(6), 552-557.

 

Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties

Kim, K.-M.; Kim, K.-H.; Kang, T.-C.; Kim, W.-Y.; Lee, M.-R.; Jung, H.-J.; Hwang, I. K.; Ko, S.-B.; Koh, J.-Y.; Won, M. H.; Oh, E.-G.; Shin, I. 

Bioorg. Med. Chem. Lett. 2003,13(14),2273-2275.

 

Di-oxanipecotic acids as more stable turn motifs than di-nipecotic acids

Baek, B.-H.; Lee, M.-R.; Kim, K.-Y.; Cho, U.-I.; Boo, D. W.; Shin, I. 

Tetrahedron Lett. 200344(17), 3447-3450.

 

De novo design of non-hydrogen-bonded helical pseudopeptides composed of oxanipecotic acid oligomers

Lee, M.-R.; Kim, K.-Y.; Cho, U.-I.; Boo, D. W.; Shin, I. 

Chem. Commun.(Cambridge, U. K.) 2003,(8), 968-969.

 

Novel consecutive beta- and gamma-turn mimetics composed of alpha-aminooxy tripeptides

Baek, B.-H.; Lee, M.-R.; Kim, K.-Y.; Cho, U.-I.; Boo, D. W.; Shin, I. 

Org Lett 20035(7), 971-974.

 

The first solid-phase synthesis of oligomeric α-aminooxy peptides

Lee, M.-R.; Lee, J.; Baek, B.-H.; Shin, I. 

Synlett 2003,(3),325-328.

 

Synthesis of novel glycopeptidomimetics containing O- and N-glycosylated α-aminooxy acids by fragment coupling on solid support

Lee, M.-R.; Lee, J.; Shin, I. 

Synlett 2002,(9),1463-1466.

 

Chemoselective ligation of maleimidosugars to peptides/protein for the preparation of neoglycopeptides/neoglycoprotein

Shin, I.; Jung, H. J.; Lee, M.-R.

Tetrahedron Lett. 2001,42(7), 1325-1328.

 

Synthesis of optically active phthaloyl D-aminooxy acids from L-amino acids or L-hydroxy acids as building blocks for the preparation of aminooxy peptides

Shin, I.; Lee, M.-R.; Lee, J.; Jung, M.; Lee, W.; Yoon, J. 

J. Org. Chem. 200065(22), 7667-7675.

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Professor Paul J. Hergenrother

hergenro@illinois.edu

261 Roger Adams Lab

600 S. Mathews Avenue

Urbana, IL 61802

The Chemistry Department at the University of Illinois

Copyright © 2014 The Hergenrother Group

Kate Neef

Administrative Assistant

kneef1@illinois.edu

245 Roger Adams Lab

#PJHteam