NOVEL GRAM-NEGATIVE ANTIBIOTICS
Multidrug-resistant Gram-negative infections are dramatically on the rise as there has not been a novel class of antibiotics approved for these pathogens since 1968. We have been working to develop rules that can predict the types of compounds that are able to accumulate in Gram-negative bacteria, and we have recently published these rules and have applied them to convert the Gram-positive-only natural product antibiotic DNM into a version that also kills Gram-negative bacteria.
Related Publications:
153.
Compound update into E. coli can be facilitated by N-alkyl guanidiniums and pyridinium
Perlmutter, S.J.; Geddes, E.J.; Drown, B.S.; Motika, S.E.; Lee, M.R.; Hergenrother, P.J.
ACS Infect. Dis., 2020, in press published on web November 24, 2020
150.
A Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch
Motika, S. E; Ulrich, R. J.; Geddes, E. J.; Lee, H. Y.; Lau, G. W.; Hergenrother, P. J.
J. Am. Chem. Soc. 2020, 142, 10856-10862
148.
Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens
Parker, E. N.; Drown, B. S.; Geddes, E. J.; Lee, H.-Y.; Ismail, N.; Lau, G. W. and Hergenrother, P. J.
Nature Microbiology 2020, 5, 67-75
141.
The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics
Richter, M. F. and Hergenrother, P. J.
Ann NY Acad Sci. 2019, 1435, 18-38.
133.
Going on offense against the Gram-negative defense
Drown, B.S. and Hergenrother, P. J.
Proc Natl. Acad. Sci. 2018, 115, 6530-6532.
130.
Broad-Spectrum Antibiotics, a Call for Chemists
Richter, M. F.; Hergenrother, P. J.
Chem 2017, 3, 10-13 (essay).
127.
Predictive Compound Accumulation Rules Yield a Broad-Spectrum Antibiotic
Richter, M. F.; Drown, B. S.; Riley, A. P.; Garcia, A.; Shirai, T.; Svec, R. L.; Hergenrother, P. J.
Nature 2017, 545, 299-304.
Antibiotics – The Perfect Storm blog
American Council on Science & Health story