NOVEL GRAM-NEGATIVE ANTIBIOTICS

Multidrug-resistant Gram-negative infections are dramatically on the rise as there has not been a novel class of antibiotics approved for these pathogens since 1968.  We have been working to develop rules that can predict the types of compounds that are able to accumulate in Gram-negative bacteria, and we have recently published these rules and have applied them to convert the Gram-positive-only natural product antibiotic DNM into a version that also kills Gram-negative bacteria.

Related Publications:

141.

The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics

Richter, M. F. and Hergenrother, P. J.

Ann NY Acad Sci. 2019, 1435, 18-38.

Link to journal

Article PDF

133.

Going on offense against the Gram-negative defense

Drown, B.S. and Hergenrother, P. J.

Proc Natl. Acad. Sci. 2018, 115, 6530-6532.

Link to journal

Article PDF    

130. 

Broad-Spectrum Antibiotics, a Call for Chemists

Richter, M. F.; Hergenrother, P. J.

Chem 2017, 3, 10-13 (essay).

 

Link to journal

Article PDF

127. 

Predictive Compound Accumulation Rules Yield a Broad-Spectrum Antibiotic

Richter, M. F.; Drown, B. S.; Riley, A. P.; Garcia, A.; Shirai, T.; Svec, R. L.; Hergenrother, P. J. 

Nature 2017, 545, 299-304.

 

Link to journal

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UIUC press release

ScienceNews highlight

Nature Microbiology blog

C&E News story

Antibiotics – The Perfect Storm blog

American Council on Science & Health story

Biotechniques highlight

Nature Biotechnology highlight

Cell Chemical Biology highlight

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Professor Paul J. Hergenrother

hergenro@illinois.edu

261 Roger Adams Lab

600 S. Mathews Avenue

Urbana, IL 61802

The Chemistry Department at the University of Illinois

Copyright © 2014 The Hergenrother Group

Kate Neef

Administrative Assistant

kneef1@illinois.edu

245 Roger Adams Lab

#PJHteam