HERGENROTHER LAB
Using small molecules to define new targets for the treatment of disease
OTHER ANTIBACTERIAL COMPOUNDS
We explore other antibacterial strategies and continuously screen our collection of unique compounds for potential antibacterial agents. Through this work we have identified compounds potent against MRSA, anti-biofilm compounds, and compounds that induce plasmid elimination from bacterial cells.
As one example, the natural product deoxynybomycin (DMN) is extremely potent against Gram-positive bacteria that are resistant to fluoroquinolones (FQs). As ~100% of MRSA and VRE are FQ-resistant, there is medicinal promise for this compound class. In 2015 we reported the synthesis of DMN and multiple derivatives. One of these compounds, called DNM-2, has outstanding oral bioavailability and rescues mice infected with MRSA.
Related Publications:
113.
Deoxynybomycins Inhibit Mutant DNA Gyrase and Rescue Mice Infected with Fluoroquinolone-Resistant Bacteria
Parkinson, E. I.; Bair, J. S.; Nakamura, B.; Lee, H. Y.; Kuttab, H. I.; Southgate, E. H.; Lezmi, S.; Lau, G. W.; Hergenrother, P. J.
Nat. Commun. 2015, 6, 6947.
87.
Identification of a Novel Protein Synthesis Inhibitor Active Against Gram-Positive Bacteria
Eibergen, N. R.; Im, I.; Patel, N. Y.; Hergenrother, P. J.
ChemBioChem 2012, 13, 574-583.
51.
Chelated Iron Sources are Inhibitors of Psudomonas aeruginosa Biofilms and Distribute Efficiently in an in vitro Model of Drug Delivery to the Human Lung
Musk, D. J.; Hergenrother, P. J.
J. Appl. Microbiol. 2008, 105, 380-388.
37.
Chemical Countermeasures for the Control of Bacterial Biofilms: Effective Compounds and Promising Targets
Musk, D. J.; Hergenrother, P. J.
Curr. Med. Chem. 2006, 13, 2163-2177 (review).
31.
Iron Salts Perturb Biofilm Formation and Disrupt Existing Biofilms of Pseudomonas aeruginosa
Musk, D. J.; Banko, D. A.; Hergenrother, P. J.
Chem. Biol. 2005, 12, 789-796.
29.
The Relationship Between Aminoglycosides' RNA Binding Proclivity and Their Antiplasmid Effect on an IncB Plasmid
Thomas, J. R.; DeNap, J. C. B.; Wong, M.; Hergenrother, P. J.
Biochemistry 2005, 44, 6800-6808.
27.
Bacterial Death comes Full Circle: Targeting Plasmid Replication in Drug-Resistant Bacteria
DeNap, J. C. B.; Hergenrother, P. J.
Org. Biomol. Chem. 2005, 3, 959-966.
25.
Combating Drug-Resistant Bacteria: Small Molecule Mimics of Plasmid Incompatibility as Antiplasmid Compounds
DeNap, J. B.; Thomas, J. R.; Musk, D. J.; Hergenrother, P. J.
J. Am. Chem. Soc. 2004, 126, 15402-15404.
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