OTHER ANTIBACTERIAL COMPOUNDS
We explore other antibacterial strategies and continuously screen our collection of unique compounds for potential antibacterial agents. Through this work we have identified compounds potent against MRSA, anti-biofilm compounds, and compounds that induce plasmid elimination from bacterial cells.
As one example, the natural product deoxynybomycin (DMN) is extremely potent against Gram-positive bacteria that are resistant to fluoroquinolones (FQs). As ~100% of MRSA and VRE are FQ-resistant, there is medicinal promise for this compound class. In 2015 we reported the synthesis of DMN and multiple derivatives. One of these compounds, called DNM-2, has outstanding oral bioavailability and rescues mice infected with MRSA.