OTHER ANTICANCER COMPOUNDS
Through our own synthesis and screening, and through work with collaborators, we have identified a multitude of other anticancer compounds. These compounds are advancing through mode-of-action studies, and through evaluation of efficacy in animal models of cancer.
Related Publications:
137.
Tunable stability of imidazotetrazines leads to a potent compound for glioblastoma
Svec, R. L.; Furiassi, L.; Skibinski, C. G.; Fan, T. M.; Riggins, G. J.; Hergenrother, P. J.
ACS Chem. Biol. 2018,13, 3206-3216.
116.
A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
Palchaudhuri, R.; Lambrecht, M. J.; Botham, R. C.; Partlow, K. C.; Van Ham, T. J.; Putt, K. S.; Nguyen, L. T.; Kim, S.-H.; Peterson, R. T.; Fan, T. M.; Hergenrother, P. J.
Cell Reports 2015, 13, 2027-2036.
103.
Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines
Han, S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.
J. Org. Chem. 2014, 79, 473-486.
100.
Synthesis and Anticancer Activity of all known (–)-Agelastatin Alkaloids
Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.
J. Org. Chem. 2013, 78, 11970-11984.
98.
Synthesis of (+/-)-Actinophyllic Acid and Analogs: Applications of Cascade Reactions and Diverted Total Synthesis
Granger, B. A.; Jewett, I, T.; Butler, J. D.; Hua, B.; Knezevic, C. E.; Parkinson, E. I.; Hergenrother, P. J.; Martin, S. F.
J. Am. Chem. Soc. 2013, 135, 12984-12986.
93.
Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids
Boyer, N.; Morrison, K. C.; Kim, J.; Hergenrother, P. J.; Movassaghi, M.
Chem. Sci. 2013, 4, 1646-1657.
81.
Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins
Risberg, K.; Guldvik, I. J.; Palchaudhuri, R.; Xi, Y.; Ju, J., Fodstad, O.; Hergenrother, P. J.; Andersson, Y.
J. Immunother. 2011, 34, 438-447.
77.
Cribostatin 6 Induces Death in Cancer Cells Through a Reactive Oxygen Species (ROS)-Mediated Mechanism
Hoyt, M.T.; Palchaudhuri, R.; Hergenrother, P. J.
Invest. New Drugs 2011, 29, 562-573.
74.
A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth that Enhances Proteasome-dependent Degradation of Estrogen Receptor α
Cherian, M. T.; Mao, C.; Aninye, I. O.; Reynolds, P. D.; Schiff, R.; Hergenrother, P. J.; Nordeen, S. K.; Wilson, E. M.; Shapiro, D. J.
J. Biol. Chem. 2010, 285, 41863-41873.
71.
Phenylcinnamides as Novel Antimitotic Agents
Leslie, B. J.; Holaday, C. R.; Nguyen, T.; Hergenrother, P. J.
J. Med. Chem. 2010, 53, 3964-3972.
70.
N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines
Stefely, J. A.; Palchaudhuri, R.; Miller, P. A.; Peterson, R. J.; Moraski, G. C.; Hergenrother, P. J.; Miller, M. J.
J. Med. Chem. 2010, 53, 3389-3395.
62.
Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Having Also Selective and Powerful Anticancer Activity
Rosenthal, A. S.; Chen, X.; Liu, J.; West, D. C.; Hergenrother, P. J.; Shapiro, T. A; Posner, G. H.
J. Med. Chem. 2009, 52, 1198-1203.
59.
Structure-Activity-Relationship of Triphenylmethylamides, Compounds that Potently Induce Apoptosis in Melanoma Cell Lines
Palchaudhuri, R.; Hergenrother, P. J.
Bioorg. Med. Chem. Lett. 2008, 18, 5888-5891.
57.
The Complex Role of the Triphenylmethyl Motif in Anti-Cancer Compounds
Palchaudhuri, R.; Nesterenko, V.; Hergenrother, P. J.
J. Am. Chem. Soc. 2008, 130, 10274-10274.
53.
A Small Molecule, Identified as an Inhibitor of the Binding of Estrogen Receptor a to Estrogen Response Elements Blocks the Estrogen-dependent Growth of Cancer Cells
Mao, C.; Patterson, N.; Cherian, M.; Aninye, I.; Zhang, C.; Patterson, N.; Cheng, J.; Putt; K. S.; Hergenrother, P. J.; Wilson, E.; Nordeen, S. K.; Shapiro, D. J.
J. Biol. Chem. 2008, 283, 12819-12830.
51.
Chelated Iron Sources are Inhibitors of Psudomonas aeruginosa Biofilms and Distribute Efficiently in an in vitro Model of Drug Delivery to the Human Lung
Musk, D. J.; Hergenrother, P. J.
J. Appl. Microbiol. 2008, 105, 380-388.
43.
A Novel Synthetic Analogue of a Constituent of Isodon excisus Inhibits Transcription of CYP1A1, -1A2, and -1B1 by Preventing Activation of the Aryl Hydrocarbon Receptor
Sienkiewicz, P.; Ciolino, H.; Leslie, B. J.; Hergenrother, P. J.; Singletary, K.; Yeh, G. C.
Carcinogenesis 2007, 28, 1052-1057.
39.
The Compound 13-D Selectively Induces Apoptosis in White Blood Cancers Versus Other Cancer Cell Types
Putt, K. S.; Nesterenko, V.; Dothager, R. S.; Hergenrother, P. J.
ChemBioChem 2006, 7, 1916-1922.
36.
Obtaining and screening compound collections: A user’s guide and a call to chemists
Hergenrother, P. J.
Curr. Opin. Chem. Biol. 2006, 10, 213-218.
30.
Synthesis and Identification of Small Molecules that Potently Induce Apoptosis in Melanoma Cell Through G1 Cell Cycle Arrest
Dothager, R. S.; Putt, K. S.; Allen, B. J.; Leslie, B. J.; Nesterenko, V.; Hergenrother, P. J.
J. Am. Chem. Soc. 2005, 127, 8686-8696.
20.
Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells
Nesterenko, V.; Putt, K. S.; Hergenrother, P. J.
J. Am. Chem. Soc. 2003, 125, 14672-14673.