OTHER ANTICANCER COMPOUNDS

Through our own synthesis and screening, and through work with collaborators, we have identified a multitude of other anticancer compounds. These compounds are advancing through mode-of-action studies, and through evaluation of efficacy in animal models of cancer.

 

Related Publications:

137.

Tunable stability of imidazotetrazines leads to a potent compound for glioblastoma

Svec, R. L.; Furiassi, L.; Skibinski, C. G.; Fan, T. M.; Riggins, G. J.; Hergenrother, P. J.

ACS Chem. Biol. 2018,13, 3206-3216.

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116.

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

Palchaudhuri, R.; Lambrecht, M. J.; Botham, R. C.; Partlow, K. C.; Van Ham, T. J.; Putt, K. S.; Nguyen, L. T.; Kim, S.-H.; Peterson, R. T.; Fan, T. M.; Hergenrother, P. J. 

Cell Reports 201513, 2027-2036.

 

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103. 

Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines

Han, S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.

J. Org. Chem. 2014, 79, 473-486.

 

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100. 

Synthesis and Anticancer Activity of all known (–)-Agelastatin Alkaloids

Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.

J. Org. Chem. 2013, 78, 11970-11984.

 

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98.

Synthesis of (+/-)-Actinophyllic Acid and Analogs: Applications of Cascade Reactions and Diverted Total Synthesis

Granger, B. A.; Jewett, I, T.; Butler, J. D.; Hua, B.; Knezevic, C. E.; Parkinson, E. I.; Hergenrother, P. J.; Martin, S. F.

J. Am. Chem. Soc. 2013, 135, 12984-12986.

 

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93. 

Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids

Boyer, N.; Morrison, K. C.; Kim, J.; Hergenrother, P. J.; Movassaghi, M.

Chem. Sci. 2013, 4, 1646-1657.

 

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MIT News Highlight

81. 

Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins

Risberg, K.; Guldvik, I. J.; Palchaudhuri, R.; Xi, Y.; Ju, J., Fodstad, O.; Hergenrother, P. J.; Andersson, Y. 

J. Immunother. 2011, 34, 438-447.

 

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77. 

Cribostatin 6 Induces Death in Cancer Cells Through a Reactive Oxygen Species (ROS)-Mediated Mechanism

Hoyt, M.T.; Palchaudhuri, R.; Hergenrother, P. J.

Invest. New Drugs 201129, 562-573.

 

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MDLinx Highlight

74. 

A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth that Enhances Proteasome-dependent Degradation of Estrogen Receptor α

Cherian, M. T.; Mao, C.; Aninye, I. O.; Reynolds, P. D.; Schiff, R.; Hergenrother, P. J.; Nordeen, S. K.; Wilson, E. M.; Shapiro, D. J.

J. Biol. Chem. 2010285, 41863-41873.

 

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71. 

Phenylcinnamides as Novel Antimitotic Agents

Leslie, B. J.; Holaday, C. R.; Nguyen, T.; Hergenrother, P. J.

J. Med. Chem. 2010, 53, 3964-3972.

 

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70. 

N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines

Stefely, J. A.; Palchaudhuri, R.; Miller, P. A.; Peterson, R. J.; Moraski, G. C.; Hergenrother, P. J.; Miller, M. J.

J. Med. Chem. 201053, 3389-3395.

 

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62. 

Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Having Also Selective and Powerful Anticancer Activity

Rosenthal, A. S.; Chen, X.; Liu, J.; West, D. C.; Hergenrother, P. J.; Shapiro, T. A; Posner, G. H.

J. Med. Chem. 200952, 1198-1203.

 

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59.

Structure-Activity-Relationship of Triphenylmethylamides, Compounds that Potently Induce Apoptosis in Melanoma Cell Lines

Palchaudhuri, R.; Hergenrother, P. J.

Bioorg. Med. Chem. Lett. 200818, 5888-5891.

 

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57.

The Complex Role of the Triphenylmethyl Motif in Anti-Cancer Compounds

Palchaudhuri, R.; Nesterenko, V.; Hergenrother, P. J.

J. Am. Chem. Soc. 2008130, 10274-10274.

 

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53.

A Small Molecule, Identified as an Inhibitor of the Binding of Estrogen Receptor a to Estrogen Response Elements Blocks the Estrogen-dependent Growth of Cancer Cells

Mao, C.; Patterson, N.; Cherian, M.; Aninye, I.; Zhang, C.; Patterson, N.; Cheng, J.; Putt; K. S.; Hergenrother, P. J.; Wilson, E.; Nordeen, S. K.; Shapiro, D. J.

J. Biol. Chem. 2008283, 12819-12830.

 

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51. 

Chelated Iron Sources are Inhibitors of Psudomonas aeruginosa Biofilms and Distribute Efficiently in an in vitro Model of Drug Delivery to the Human Lung

Musk, D. J.; Hergenrother, P. J.

J. Appl. Microbiol2008105, 380-388.

 

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43.

A Novel Synthetic Analogue of a Constituent of Isodon excisus Inhibits Transcription of CYP1A1, -1A2, and -1B1 by Preventing Activation of the Aryl Hydrocarbon Receptor

Sienkiewicz, P.; Ciolino, H.; Leslie, B. J.; Hergenrother, P. J.; Singletary, K.; Yeh, G. C.

Carcinogenesis 200728, 1052-1057.

 

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39. 

The Compound 13-D Selectively Induces Apoptosis in White Blood Cancers Versus Other Cancer Cell Types

Putt, K. S.; Nesterenko, V.; Dothager, R. S.; Hergenrother, P. J. 

ChemBioChem 20067, 1916-1922.

 

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36.

Obtaining and screening compound collections: A user’s guide and a call to chemists

Hergenrother, P. J.

Curr. Opin. Chem. Biol. 200610, 213-218.

 

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30. 

Synthesis and Identification of Small Molecules that Potently Induce Apoptosis in Melanoma Cell Through G1 Cell Cycle Arrest

Dothager, R. S.; Putt, K. S.; Allen, B. J.; Leslie, B. J.; Nesterenko, V.; Hergenrother, P. J.

J. Am. Chem. Soc. 2005127, 8686-8696.

 

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Chemical & Engineering News Highlight

20. 

Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells

Nesterenko, V.; Putt, K. S.; Hergenrother, P. J.

J. Am. Chem. Soc. 2003125, 14672-14673.

 

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Chemical & Engineering News Highlight

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Professor Paul J. Hergenrother

hergenro@illinois.edu

261 Roger Adams Lab

600 S. Mathews Avenue

Urbana, IL 61802

The Chemistry Department at the University of Illinois

Copyright © 2014 The Hergenrother Group

Julie Bass

Administrative Assistant

jlbass2@illinois.edu

245 Roger Adams Lab

#PJHteam