HERGENROTHER LAB
Using small molecules to define new targets for the treatment of disease
OTHER ANTICANCER COMPOUNDS
Through our own synthesis and screening, and through work with collaborators, we have identified a multitude of other anticancer compounds. These compounds are advancing through mode-of-action studies, and through evaluation of efficacy in animal models of cancer.
Related Publications:
137.
Tunable stability of imidazotetrazines leads to a potent compound for glioblastoma
Svec, R. L.; Furiassi, L.; Skibinski, C. G.; Fan, T. M.; Riggins, G. J.; Hergenrother, P. J.
ACS Chem. Biol. 2018,13, 3206-3216.
116.
A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
Palchaudhuri, R.; Lambrecht, M. J.; Botham, R. C.; Partlow, K. C.; Van Ham, T. J.; Putt, K. S.; Nguyen, L. T.; Kim, S.-H.; Peterson, R. T.; Fan, T. M.; Hergenrother, P. J.
Cell Reports 2015, 13, 2027-2036.
103.
Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines
Han, S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.
J. Org. Chem. 2014, 79, 473-486.
100.
Synthesis and Anticancer Activity of all known (–)-Agelastatin Alkaloids
Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.
J. Org. Chem. 2013, 78, 11970-11984.
98.
Synthesis of (+/-)-Actinophyllic Acid and Analogs: Applications of Cascade Reactions and Diverted Total Synthesis
Granger, B. A.; Jewett, I, T.; Butler, J. D.; Hua, B.; Knezevic, C. E.; Parkinson, E. I.; Hergenrother, P. J.; Martin, S. F.
J. Am. Chem. Soc. 2013, 135, 12984-12986.
93.
Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids
Boyer, N.; Morrison, K. C.; Kim, J.; Hergenrother, P. J.; Movassaghi, M.
Chem. Sci. 2013, 4, 1646-1657.
81.
Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins
Risberg, K.; Guldvik, I. J.; Palchaudhuri, R.; Xi, Y.; Ju, J., Fodstad, O.; Hergenrother, P. J.; Andersson, Y.
J. Immunother. 2011, 34, 438-447.
77.
Cribostatin 6 Induces Death in Cancer Cells Through a Reactive Oxygen Species (ROS)-Mediated Mechanism
Hoyt, M.T.; Palchaudhuri, R.; Hergenrother, P. J.
Invest. New Drugs 2011, 29, 562-573.
74.
A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth that Enhances Proteasome-dependent Degradation of Estrogen Receptor α
Cherian, M. T.; Mao, C.; Aninye, I. O.; Reynolds, P. D.; Schiff, R.; Hergenrother, P. J.; Nordeen, S. K.; Wilson, E. M.; Shapiro, D. J.
J. Biol. Chem. 2010, 285, 41863-41873.
71.
Phenylcinnamides as Novel Antimitotic Agents
Leslie, B. J.; Holaday, C. R.; Nguyen, T.; Hergenrother, P. J.
J. Med. Chem. 2010, 53, 3964-3972.
70.
N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines
Stefely, J. A.; Palchaudhuri, R.; Miller, P. A.; Peterson, R. J.; Moraski, G. C.; Hergenrother, P. J.; Miller, M. J.
J. Med. Chem. 2010, 53, 3389-3395.
62.
Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Having Also Selective and Powerful Anticancer Activity
Rosenthal, A. S.; Chen, X.; Liu, J.; West, D. C.; Hergenrother, P. J.; Shapiro, T. A; Posner, G. H.
J. Med. Chem. 2009, 52, 1198-1203.
59.
Structure-Activity-Relationship of Triphenylmethylamides, Compounds that Potently Induce Apoptosis in Melanoma Cell Lines
Palchaudhuri, R.; Hergenrother, P. J.
Bioorg. Med. Chem. Lett. 2008, 18, 5888-5891.
57.
The Complex Role of the Triphenylmethyl Motif in Anti-Cancer Compounds
Palchaudhuri, R.; Nesterenko, V.; Hergenrother, P. J.
J. Am. Chem. Soc. 2008, 130, 10274-10274.
53.
A Small Molecule, Identified as an Inhibitor of the Binding of Estrogen Receptor a to Estrogen Response Elements Blocks the Estrogen-dependent Growth of Cancer Cells
Mao, C.; Patterson, N.; Cherian, M.; Aninye, I.; Zhang, C.; Patterson, N.; Cheng, J.; Putt; K. S.; Hergenrother, P. J.; Wilson, E.; Nordeen, S. K.; Shapiro, D. J.
J. Biol. Chem. 2008, 283, 12819-12830.
51.
Chelated Iron Sources are Inhibitors of Psudomonas aeruginosa Biofilms and Distribute Efficiently in an in vitro Model of Drug Delivery to the Human Lung
Musk, D. J.; Hergenrother, P. J.
J. Appl. Microbiol. 2008, 105, 380-388.
43.
A Novel Synthetic Analogue of a Constituent of Isodon excisus Inhibits Transcription of CYP1A1, -1A2, and -1B1 by Preventing Activation of the Aryl Hydrocarbon Receptor
Sienkiewicz, P.; Ciolino, H.; Leslie, B. J.; Hergenrother, P. J.; Singletary, K.; Yeh, G. C.
Carcinogenesis 2007, 28, 1052-1057.
39.
The Compound 13-D Selectively Induces Apoptosis in White Blood Cancers Versus Other Cancer Cell Types
Putt, K. S.; Nesterenko, V.; Dothager, R. S.; Hergenrother, P. J.
ChemBioChem 2006, 7, 1916-1922.
36.
Obtaining and screening compound collections: A user’s guide and a call to chemists
Hergenrother, P. J.
Curr. Opin. Chem. Biol. 2006, 10, 213-218.
30.
Synthesis and Identification of Small Molecules that Potently Induce Apoptosis in Melanoma Cell Through G1 Cell Cycle Arrest
Dothager, R. S.; Putt, K. S.; Allen, B. J.; Leslie, B. J.; Nesterenko, V.; Hergenrother, P. J.
J. Am. Chem. Soc. 2005, 127, 8686-8696.
20.
Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells
Nesterenko, V.; Putt, K. S.; Hergenrother, P. J.
J. Am. Chem. Soc. 2003, 125, 14672-14673.