PUBLICATIONS

146.

Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential

Boudreau, M. W.; Peh, J.; Hergenrother, P. J.

ACS Chem. Biol2019, published on web July 1, 2019

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Meet the Authors

145.

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

Llabani, E.; Hicklin, R. W.; Lee, H.-Y.; Motika, S. E.; Crawford, L. A.; Weerapana, E., Hergenrother, P. J.

Nature Chem. 2019, 11, 521

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Nature Chem. highlight

144.

Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

Thirawatananond, P.; McPherson, R. L.; Malhi, J.; Nathan, S.; Lambrecht, M.J.; Brichacek, M.; Hergenrother, P.J.; Leung, A.K.L.; Gabelli, S.B.

Sci. Reports20199, 5940

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143.

Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

Schlein, L. J.; Fadl-Alla, B.; Pondenis, H. C.; Lezmi, S.; Eberhart, C. G.; LeBlanc, A. K.; Dickinson, P. J.; Hergenrother, P. J.; Fan, T. M.

Front. Oncol. 20199, 96

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142.

Enantioselective synthesis of isocarbostyril alkaloids and analogs using catalytic dearomative functionalization of benzene

Bingham, T. W.; Hernandez, L. W.; Olson, D. G.; Svec, R. L.; Hergenrother, P. J.; Sarlah, D

J. Am. Chem. Soc. 2019, 141, 657-670

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141.

The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics

Richter, M. F. and Hergenrother, P. J.

Ann NY Acad Sci. 2019, 1435, 18-38.

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140.

(ADP-ribosyl)hydrolases: Structural basis for differential substrate recognition and inhibition

Rack, J.G.M.; Ariza, A.; Drown, B. S.; Henfrey, C.; Shirai, T.; Hergenrother, P. J.; Ahel, I.

Cell Chem. Biol. 2018, 25, 1533-1546

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139.

Oxygen starvation unmasks a killer

Svec, R. L. and Hergenrother, P. J.

Cell Chem. Biol. 2018, 25, 1313-1314.

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138.

Monitoring poly(ADP-ribosyl)glycohydrolase activity with a continuous fluorescent substrate

Drown, B. S.; Shirai, T.; Rack, J.G.M.; Ahel, I.; Hergenrother, P. J.

Cell Chem. Biol. 2018, 25, 1562-1570

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137.

Tunable stability of imidazotetrazines leads to a potent compound for glioblastoma

Svec, R. L.; Furiassi, L.; Skibinski, C. G.; Fan, T. M.; Riggins, G. J.; Hergenrother, P. J.

ACS Chem. Biol. 2018,13, 3206-3216.

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Selected as ACS Editors' Choice publication for Nov. 8, 2018

C&E News story

136.

Preparation of structurally diverse compounds from the natural product lycorine

Tasker, S. Z.; Cowfer, A. E.; Hergenrother P. J.

Org. Lett. 2018, 20, 5894-5898.

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135.

Overcoming resistance to targeted anticancer therapies through small-molecule mediated MEK degradation

Peh, J.; Boudreau, M. W.; Smith, H. M.; and Hergenrother, P. J.

Cell Chem. Biol. 2018, 25, 996-1005.

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Cell Chemical Biology highlight

Science Trends highlight

134.

Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death

Livezey, M.; Huang, R.;Hergenrother, P. J.; Shapiro, D.S.

Cell Death Differ. 2018, 25, 1796-1807.

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133.

Going on offense against the Gram-negative defense

Drown, B.S. and Hergenrother, P. J.

Proc Natl. Acad. Sci. 2018, 115, 6530-6532.

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132.

How many human proteoforms are there?

Aebersold, R; Agar, J.N.; Amster, I.J.; Baker, M.S.; Bertozzi, C.R.; Boja, E.S.; Costello, C.E.; Cravatt, B.F.; Fenselau, C., Garcia, B.A.; Ge, Y.; Gunawardena, J.; Hendrickson, R.C.; Hergenrother, P.J.; Huber, C.G.; Ivanov, A.R.; Jensen, O.N.; Jewett, M.C.; Kelleher, N.L.; Kiessling, L.L.; Krogan, N.J.; Larsen, M.R.; Loo, J.A.; Ogorzalek Loo, R.R.; Lundberg, E.; MacCoss, M.J.; Mallick, P.; Mootha, V.K.; Mrksich, M.; Muir, T.W.; Patrie, S.M.; Pesavento, J.J.; Pitteri, S.J.; Rodriguez, H.; Saghatelian, A.; Sandoval, W.; Schlüter, H.; Sechi, S.; Slavoff, S.A.; Smith, L.M.; Snyder, M.P.; Thomas, P.M.; Uhlén, M.; Van Eyk, J.E.; Vidal, M.; Walt, D.R.; White, F.M.; Williams, E.R.; Wohlschlager, T.; Wysocki, V.H.; Yates, N.A.; Young, N.L.; Zhang, B.  

Nature Chem. Biol. 201814, 206-214.

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131.

Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNBI expression   

Doganay, S.; Lee, M. Y.; Baum, A.; Peh, J.; Hwang, S. Y.; Yoo, J. Y.; Hergenrother, P. J.; Garcia-Sastre, A.; Myong, S.; Ha, T.  

Integr. Biol. 20179, 857-867.

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130. 

Broad-Spectrum Antibiotics, a Call for Chemists

Richter, M. F.; Hergenrother, P. J.

Chem 2017, 3, 10-13 (essay).

 

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129. 

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

Joshi, A. D.; Botham, R. C.; Schlein, L. J.; Roth, H. S.; Mangraviti, A.; Borodovsky, A.; Tyler, B.; Joslyn, S.; Looper, J. S.; Podell, M.; Fan, T. F.; Hergenrother, P. J.; Riggins, G. J.

Oncotarget 2017, 8, 80124-80138.

 

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128. 

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer

Granchi, C.; Fortunato, S.; Meni, S.; Rizzolio, F.; Caligiuri, I.; Tuccinardi, T.; Lee, H.-Y.; Hergenrother, P. J.; Minutolo, F.

J. Agric. Food Chem. 2017, 65, 5639-5649.

 

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127. 

Predictive Compound Accumulation Rules Yield a Broad-Spectrum Antibiotic

Richter, M. F.; Drown, B. S.; Riley, A. P.; Garcia, A.; Shirai, T.; Svec, R. L.; Hergenrother, P. J. 

Nature 2017, 545, 299-304.

 

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UIUC press release

ScienceNews highlight

Nature Microbiology blog

C&E News story

Antibiotics – The Perfect Storm blog

American Council on Science & Health story

Biotechniques highlight

Nature Biotechnology highlight

Cell Chemical Biology highlight

126. 

Taming Reactive Benzynes

Tasker, S. Z.; Hergenrother, P. J.

Nature Chem. 2017, 9, 504-506 (News & Views).

 

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124. 

Pharmacokinetics and Derivation of an Anticancer Dosing Regimen for the Novel Anti-Cancer Agent Isobutyl-Deoxynyboquinone (IB-DNQ), a NQO1 Bioactivatable Molecule, in the Domestic Felid Species

Lundberg, A. P.; Francis, J. M.; Pajak, M.; Parkinson, E. I.; Wycislo, K. L.; Rosol, T. J.; Brown, M. E.; London, C. A.; Dirikolu, L.; Hergenrother, P. J.; Fan. T. M.

Invest New Drugs 2017, 35, 134-144.

 

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125. 

Reactive Oxygen Species Synergize to Potently and Selectively Induce Cancer Cell Death

Lee, H.-Y.; Parkinson, E. I.; Granchi, C.; Paterni, I.; Panigrahy, D.; Seth, P.; Minutolo, F.; Hergenrother, P. J.

ACS Chem. Biol. 2017, 12, 1416-1424.

 

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123. 

Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine

Garcia, A.; Drown, B. S.; Hergenrother, P. J.

Org. Lett. 201618, 4852-4855.

 

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122. 

Porous Photonic Crystal External Cavity Laser Biosensor

Huang, Q.; Peh, J.; Hergenrother, P. J.; Cunningham, B. T.

Appl. Phys. Lett. 2016, 109, 071103.

 

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121. 

Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics

Botham, R. C.; Roth, H. S.; Book, A. P.; Roady, P. J.; Fan, T. M.; Hergenrother, P. J.

ACS Central Science 2016, 2, 545-559.

 

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120. 

Targeting Multidrug-resistant Ovarian Cancer Through Estrogen Receptor α Dependent ATP Depletion Caused by Hyperactivation of the Unfolded Protein Response

Zheng, Z.; Andruska, N. D.; Lambrecht, M. L.; Sisi, H.; Hergenrother, P. J.; Nelson, E.; Shapiro, D. J. 

Oncotarget 2016, 9, 14741-14753.

 

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119. 

The Combination of Vemurafenib and Procaspase-3 Activation is Synergistic in Mutant BRAF Melanomas

Peh, J.; Fan, T. M.; Wycislo, K. L.; Roth, H. S.; Hergenrother, P. J.

Mol. Cancer Ther. 2016, 15, 1859-1869.

 

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118. 

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy

Luu, L. M.; Nguyen, L.; Peng, S.; Lee, J.; Lee, H. Y.; Wong, C. H.; Hergenrother, P. J.; Chan, H. Y.; Zimmerman, S. C.

ChemMedChem 2016, 11, 1428-1435.

 

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117. 

Derivatives of Procaspase-Activating Compound 1 (PAC-1) and Their Anticancer Activities

Roth, H. S.; Hergenrother, P. J.

Curr. Med. Chem. 2016, 23, 201-241 (review).

 

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116. 

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

Palchaudhuri, R.; Lambrecht, M. J.; Botham, R. C.; Partlow, K. C.; Van Ham, T. J.; Putt, K. S.; Nguyen, L. T.; Kim, S.-H.; Peterson, R. T.; Fan, T. M.; Hergenrother, P. J.

Cell Reports 201513, 2027-2036.

 

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115.

Deoxynyboquinones as NQO1-Activated Cancer Therapeutics

Parkinson, E. I.; Hergenrother, P. J.

Acc. Chem. Res. 201548, 2715-2733.

 

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114.

Salicylketoximes that Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

Granchi, C.; Qian, Y.; Lee, H. Y.; Paterni, I.; Pasero, C.; Iegre, J.; Carlson, K. E.; Tuccinardi, T.; Chen, X.; Katzenellenbogen, J. A.; Hergenrother, P. J.; Minutolo, F.

ChemMedChem 201510, 1892-1900.

 

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113.

Deoxynybomycins Inhibit Mutant DNA Gyrase and Rescue Mice Infected with Fluoroquinolone-Resistant Bacteria

Parkinson, E. I.; Bair, J. S.; Nakamura, B.; Lee, H. Y.; Kuttab, H. I.; Southgate, E. H.; Lezmi, S.; Lau, G. W.; Hergenrother, P. J.  

Nat. Commun. 20156, 6947.

 

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112.

Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics

Roth, H. S.; Botham, R. C.; Schmid, S. C.; Fan, T. M.; Dirikolu, L.; Hergenrother, P. J.  

J. Med. Chem. 201558, 4046-4065.

 

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111.

Synthesis and Biological Evaluation of Non-Glucose Glycoconjugated N-Hydroyxindole Class LDH Inhibitors as Anticancer Agents

DiBussolo, V.; Calvaresi, E. C.; Granchi, C.; DelBino, L.; Frau, I.; Lang, M.; Tuccinardi, T.; Macchia, M.; Matinelli, A.; Hergenrother, P. J.; Minutolo, F.  

RSC Adv. 20155, 19944-19954.

 

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110.

Synthesis of Dimeric ADP-Ribose and Its Structure with Human Poly(ADP-Ribose) Glycohydrolase

Lambrecht, M. J.; Brichacek, M.; Barkauskaite, E.; Ariza, A.; Ahel, I.; Hergenrother, P. J.  

J. Am. Chem. Soc. 2015137, 3558-3564.

 

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109.

Synthesis of Bridged Oxafenestranes from Pleuromutilin

Hicklin, R. W.; López Silva, T. L.; Hergenrother, P. J.  

Angew. Chem. Int. Ed. 201453, 9880-9883.

 

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108.

Detection of Protein-Small Molecule Binding Using a Self-Referencing External Cavity Laser Biosensor

Zhang, M.; Peh, J.; Hergenrother, P. J.; Cunningham, B. T.  

J. Am. Chem. Soc. 2014136, 5840-5843.

 

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107.

Targeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor

Wong, C.-H.; Nguyen, L.; Peh, J.; Luu, L. M.; Sanchez, J. S.; Richardson, S. L.; Tuccinardi, T.; Tsoi, H.; Chan, W. Y.; Chan, H. Y. E.; Baranger, A. M.; Hergenrother, P. J.; Zimmerman, S. C.

J. Am. Chem. Soc. 2014136, 6355-6361.

 

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106. 

Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity.

Botham, R. C.; Fan, T. M.; Im, I.; Borst, L. B.; Dirikolu, L.; Hergenrother, P. J.  

J. Am. Chem. Soc. 2014136, 1312-1319.

 

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105. 

Light Activation of Staphylococcus aureus Toxin YoeBSa1 Reveals Guanosine-Specific Endoribonuclease Activity

Larson, A. S.; Hergenrother, P. J.  

Biochemistry 201453, 188-201.

 

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104. 

Synthesis of Complex and Diverse Compounds through Ring Distortion of Abietic Acid

Rafferty, R. J.; Hicklin, R. W.; Maloof, K. A.; Hergenrother, P. J.  

Angew. Chem. Int. Ed. 201453, 220-224.

 

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103. 

Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines

Han, S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M. 

J. Org. Chem. 201479, 473-486.

 

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102. 

Natural Products as Starting Points for the Synthesis of Complex and Diverse Compounds

Morrison, K. C.; Hergenrother, P. J.  

Nat. Prod. Rep. 201431, 6-14.

 

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101. 

Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor

Calvaresi, E. C.; Granchi, C.; Tuccinardi, T.; DiBussolo, V.; Huigens, R. W.; Lee, H.-Y.; Palchaudhuri, R.; Macchia, M.; Martinelli, A.; Minutolo, F.; Hergenrother, P. J.

ChemBioChem 201314, 2263-2267.

 

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100. 

Synthesis and Anticancer Activity of All Known (–)-Agelastatin Alkaloids 

Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.  

J. Org. Chem. 201378, 11970-11984.

 

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99. 

Detection of Endogenous MazF Enzymatic Activity in Staphylococcus aureus

van Rensburg, J. J.; Hergenrother, P. J.

Anal. Biochem. 2013443, 81-87.

 

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98. 

Synthesis of (+/-)-Actinophyllic Acid and Analogs: Applications of Cascade Reactions and Diverted Total Synthesis

Granger, B. A.; Jewett, I. T.; Butler, J. D.; Hua, B.; Knezevic, C. E.; Parkinson, E. I.; Hergenrother, P. J.; Martin, S. F.

J. Am. Chem. Soc. 2013135,12984-12986.

 

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97. 

Efficient NQO1 Substrates are Potent and Selective Anticancer Agents

Parkinson, E. I.; Bair, J. S.; Cismesia, M.; Hergenrother, P. J. 

ACS Chem. Biol. 20138, 2173-2183.

 

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Meet the Authors

96. 

Assessing the Differential Action on Cancer Cells of LDH-A Inhibitors based on the N-Hydroxyindole-2-Carboxylate (NHI) and Malonic (Mal) Scaffolds

Granchi, C.; Calvaresi, E. C.; Tuccinardi, T.; Paterni, I.; Macchia, M.; Martinelli, A.; Hergenrother, P. J.; Minutolo, F. 

Org. Biomol. Chem. 201311, 6588-6596.

 

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95. 

Glucose conjugation for the specific targeting and treatment of cancer

Calvaresi, E. C.; Hergenrother, P. J.  

Chem. Sci. 20134, 2319-2333.

 

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RSC Highlight

Chemical Biology 

Interface Highlight

94. 

External Cavity Laser Biosensor

Ge, C.; Lu, M.; George, S.; Flood, T. A.; Wagner, C.; Zheng, J.; Pokhriyal, A.; Eden, J. G.; Hergenrother, P. J.; Cunningham, B. T.  

Lab Chip 201313, 1247-1256.

 

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UIUC News

Highlight

93. 

Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids

Boyer, N.; Morrison, K. C.; Kim, J.; Hergenrother, P. J.; Movassaghi, M. 

Chem. Sci. 20134, 1646-1657.

 

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MIT News Highlight

92. 

A Ring Distortion Strategy to Construct Stereochemically Complex and Structurally Diverse Compounds from Natural Products

Huigens, R. W.; Morrison, K. C.; Hicklin, R. W.; Flood, T. A.; Richter, M. F.; Hergenrother, P. J.

Nature Chem. 20135, 195-202.

 

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C&E News Highlight 

Faculty of 1000 Highlight 

Nature Chemistry News

YouTube Animation

91. 

Structure and Mechanism of a Canonical Poly(ADP-Ribose) Glycohydrolase

Dunstan, M. S.; Barkauskaite, E.; Lafite, P.; Knezevic, C. E.; Brassington, A.; Ahel, M.; Hergenrother, P. J.; Leys, D.; Ahel, I.  

Nat. Commun. 20123, 878.

 

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90. 

An NQO1 Substrate with Potent Anti-Tumor Activity that Selectively Kills by PARP-1-Induced Programmed Necrosis

Huang, X.; Dong, Y.; Bey, E. A.; Kilgore, J. A.; Bair, J. S.; Li, L.-S.; Patel, M.; Parkinson, E. I.; Wang, Y.; Williams, N. S.; Gao, J.; Hergenrother, P. J.; Boothman, D. A. 

Cancer Res. 201272, 3038-3047.

 

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89. 

Differential effects of procaspase-3 activating compounds in the induction of cancer cell death

West, D. C.; Qin, Y.; Peterson, Q. P.; Thomas, D. L.; Palchaudhuri, R. P.; Morrison, K. C.; Lucas, P. W.; Palmer, A. E.; Fan, T. M; Hergenrother, P. J.

Mol. Pharmaceutics 20129, 1425-1434.

 

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88. 

Artificial Activation of Toxin-Antitoxin Systems as an Antibacterial Strategy

Williams, J. J.; Hergenrother, P. J.

Trends Microbiol. 201220, 291-298.

 

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Faculty of 1000

Highlight

87. 

Identification of a Novel Protein Synthesis Inhibitor Active Against Gram-Positive Bacteria

Eibergen, N. R.; Im, I.; Patel, N. Y.; Hergenrother, P. J.  

ChemBioChem 201213, 574-583. 

 

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86. 

Selective Small Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)

Finch, K. E.; Knezevic, C. E.; Nottbohm, A. C.; Partlow, K. C.; Hergenrother, P. J.

ACS Chem. Biol. 20127, 563-570. 

 

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Meet the Authors

85.

Whole Cell Microtubule Analysis by Flow Cytometry

Morrison, K.C.; Hergenrother, P. J.  

Anal. Biochem. 2012420, 26-32. 

 

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84. 

Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)

Hsu, D. C.; Roth, H. S.; West, D. C.; Botham, R. C.; Novotny, C. J.; Schmid, S. C.; Hergenrother, P. J. 

ACS Comb. Sci. 201214, 44-50. 

 

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83. 

Runaway ROS as a Selective Anticancer Strategy

Parkinson, E. I.; Hergenrother, P. J.  

ChemMedChem 20116, 1957-1959. 

 

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82. 

Toxin-Antitoxin (TA) Systems are Prevalent and Transcribed in Clinical Isolates of Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus

Williams, J. J.; Halvorsen, E. M.; Dwyer, E. M.; DiFazio, R. M.; Hergenrother, P. J.  

FEMS Microbiol. Lett. 2011322, 41-50. 

 

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81. 

Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins

Risberg, K.; Guldvik, I. J.; Palchaudhuri, R.; Xi, Y.; Ju, J.; Fodstad, O.; Hergenrother, P. J.; Andersson, Y. 

J. Immunother. 201134, 438-447. 

 

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80. 

Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents Against Cancer Cells

Granchi, C.; Roy, S.; Giacomelli, C.; Macchia, M.; Tuccinardi, T.; Martinelli, A.; Lanza, M.; Betti, L.; Giannaccini, G.; Lucacchini, A.; Funel, N.; Leon, L. G.; Giovannetti, E.; Peters, G. J.; Palchaudhuri, R.; Calvaresi, E. C.; Hergenrother, P. J.; Minutolo, F.

J. Med. Chem. 201154, 1599-1612. 

 

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79. 

Txe, an Endoribonuclease of the Enterococcal Axe-Txe Toxin-Antitoxin System, cleaves mRNA and inhibits protein synthesis

Halvorsen, E. M.; Williams, J. J.; Bhimani, A. J.; Billings, E. A.; Hergenrother, P. J. 

Microbiology 2011157, 387-397. 

 

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78. 

Transcript Profiling and RNA Interference as Tools to Identify Small Molecule Mechanisms and Therapeutic Potential

Palchaudhuri, R.; Hergenrother, P. J.  

ACS Chem. Biol. 20116, 21-33. 

 

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77. 

Cribostatin 6 Induces Death in Cancer Cells Through a Reactive Oxygen Species (ROS)-Mediated Mechanism

Hoyt, M.T.; Palchaudhuri, R.; Hergenrother, P. J.

Invest. New Drugs 201129, 562-573. 

 

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MDLinx Highlight

76. 

High-Throughput Screening for Modulators of Protein-Protein Interactions: Use of Photonic Crystal Biosensors and Complementary Technologies

Heeres, J. T.; Hergenrother, P. J. 

Chem. Soc. Rev. 201140, 4398-4410. 

 

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75. 

Pharmacokinetics and Derivation of an Anticancer Dosing Regimen for PAC-1, a Preferential Small Molecule Activator of Procaspase-3, in Healthy Dogs

Lucas, P. W.; Schmit, J. M.; Peterson, Q. P.; West, D. C.; Hsu, D. C.; Novotny, C. J.; Dirikoul, L.; Deorge, D. R.; Garrett, L. D.; Hergenrother, P. J.; Fan, T. M. 

Invest. New Drugs 201129, 901-911. 

 

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74. 

A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth that Enhances Proteasome-dependent Degradation of Estrogen Receptor α

Cherian, M. T.; Mao, C.; Aninye, I. O.; Reynolds, P. D.; Schiff, R.; Hergenrother, P. J.; Nordeen, S. K.; Wilson, E. M.; Shapiro, D. J. 

J. Biol. Chem. 2010285, 41863-41873. 

 

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73. 

Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3-Activating Compound

Peterson, Q. P.; Hsu, D. C.; Novotny, C. J.; West, D. C.; Kim, D.; Schmit, J. M.; Dirikolu, L.; Hergenrother, P. J.; Fan, T. M.  

Cancer Res. 201070, 7232-7241.

 

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72. 

Identification of Novel Synthetic Toll-Like Receptor 2 Agonists by High-Throughput Screening

Guan, Y.; Omueti-Ayoade, K.; Mutha, S. K.; Hergenrother, P. J.; Tapping, R. I. 

J. Biol. Chem. 2010285, 23755-23763.

 

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71. 

Phenylcinnamides as Novel Antimitotic Agents

Leslie, B. J.; Holaday, C. R.; Nguyen, T.; Hergenrother, P. J.  

J. Med. Chem. 2010, 53, 3964-3972. 

 

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70. 

N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines

Stefely, J. A.; Palchaudhuri, R.; Miller, P. A.; Peterson, R. J.; Moraski, G. C.; Hergenrother, P. J.; Miller, M. J. 

J. Med. Chem. 201053, 3389-3395.

 

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69. 

Chemistry and Biology of Deoxynyboquinone, a Potent Inducer of Cancer Cell Death

Bair, J. S.; Palchaudhuri, R.; Hergenrother, P. J. 

J. Am. Chem. Soc. 2010132, 5469-5478.

 

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68. 

Preparation of the Caspase-3/7 Substrate Ac-DEVD-pNA by Solution-Phase Peptide Synthesis

Peterson, Q. P.; Goode, D. R.; West, D. C.; Botham, R. C.; Hergenrother, P. J. 

Nature Protocols 20105, 294-302.

 

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67. 

Identifying Modulators of Protein-Protein Interactions Using Photonic Crystal Biosensors

Heeres, J. T.; Kim, S.-H.; Leslie, B. J.; Lidstone, E. A.; Cunningham, B. T.; Hergenrother, P. J.  

J. Am. Chem. Soc. 2009131, 18202-18203.

 

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BioPhotonics Highlight

66. 

A Method for Identifying Small Molecule Aggregators Using Photonic Crystal Biosensor Microplates 

Chan, L. L; Lidstone, E. A.; Finch, K. E.; Heeres, J. T.; Hergenrother, P. J.; Cunningham, B. T. 

J. Lab. Autom. 200914, 348-359.

 

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65. 

Procaspase-3 Activation as an Anti-Cancer Strategy: Structure-Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and Its Cellular Co-Localization with Caspase-3

Peterson, Q. P.; Hsu, D. C.; Goode, D. R.; Novotny, C. J.; Totten, R. K.;  Hergenrother, P. J. 

J. Med. Chem. 200952, 5721-5731.

 

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64. 

Small Molecule Ligands for Bulged RNA Secondary Structures 

Meyer, S. T.; Hergenrother, P. J.

Org. Lett. 200911, 4052-4055.

 

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63. 

PAC-1 Activates Procaspase-3 in vitro Through Relief of Zinc-Mediated Inhibition 

Peterson, Q. P.; Goode, D. R.; West, D. C.; Ramsey, K. N.; Lee, J. J.; Hergenrother, P. J. 

J. Mol. Biol. 2009388, 144-158.

 

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62. 

Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Having Also Selective and Powerful Anticancer Activity 

Rosenthal, A. S.; Chen, X.; Liu, J.; West, D. C.; Hergenrother, P. J.; Shapiro, T. A; Posner, G. H. 

J. Med. Chem. 200952, 1198-1203.

 

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61. 

The Total Synthesis and Cytoprotective Properties of Dykellic Acid 

Thompson, C. M.; Quinn, C. A.;  Hergenrother, P. J. 

J. Med. Chem. 200952, 117-125.

 

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60. 

Phosphate Mimics: Cyclic Compounds

Nottbohm, A. C.; Hergenrother, P. J. 

Wiley Encyclopedia of Chemical Biology 2008, 1-15.

 

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Buy the encyclopedia!

59. 

Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells 

Palchaudhuri, R.; Hergenrother, P. J. 

Bioorg. Med. Chem. Lett. 200818, 5888-5891.

 

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58. 

Exposing Plasmids as the Achilles' Heel of Drug-Resistant Bacteria

Williams, J. J.; Hergenrother, P. J. 

Curr. Opin. Chem. Biol. 200812, 389-399.

 

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57. 

The Complex Role of the Triphenylmethyl Motif in Anticancer Compounds 

Palchaudhuri, R.; Nesterenko, V.; Hergenrother, P. J. 

J. Am. Chem. Soc. 2008130, 10274-10274.

 

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56. 

A General Method for Discovering Inhibitors of Protein-DNA Interactions Using Photonic Crystal Biosensors 

Chan, L. C.; Pineda, M.; Heeres, J. T.; Hergenrother, P. J.; Cunningham, B. T. 

ACS Chem. Biol. 20083, 437-448.

 

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About the Authors

RSC News Highlight

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Photonics.com Highlight

55. 

Identification of the Cellular Targets of Bioactive Small Organic Molecules Using Affinity Reagents 

Leslie, B. J.; Hergenrother, P. J. 

Chem. Soc. Rev. 200837, 1347-1360.

 

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54. 

Identification of Promiscuous Small Molecule Activators in High-Throughput Enzyme Activation Screens 

Goode, D. R.; Totten, R. K.; Heeres, J. T.; Hergenrother, P. J. 

J. Med. Chem. 200851, 2346-2349.

 

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53. 

A Small Molecule, Identified as an Inhibitor of the Binding of Estrogen Receptor a to Estrogen Response Elements Blocks the Estrogen-dependent Growth of Cancer Cells

Mao, C.; Patterson, N.; Cherian, M.; Aninye, I.; Zhang, C.; Patterson, N.; Cheng, J.; Putt, K. S.; Hergenrother, P. J.; Wilson, E.; Nordeen, S. K.; Shapiro, D. J.

J. Biol. Chem. 2008283, 12819-12830.

 

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52. 

Targeting RNA with Small Molecules 

Thomas, J. R.; Hergenrother, P. J. 

Chem. Rev. 2008108, 1171-1224.

 

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51. 

Chelated Iron Sources are Inhibitors of Psudomonas aeruginosa Biofilms and Distribute Efficiently in an in vitro Model of Drug Delivery to the Human Lung

Musk, D. J.; Hergenrother, P. J.

J. Appl. Microbiol. 2008105, 380-388.

 

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50. 

DNA as a Target for Anti-Cancer Compounds: Methods to Determine the Mode of Binding and the Mechanism of Action 

Palchaudhuri, R.; Hergenrother, P. J. 

Curr. Opin. Biotechnol. 200718, 497-503.

 

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49. 

Poly(ADP-Ribose) Makes a Date with Death 

Heeres, J. T.; Hergenrother, P. J. 

Curr. Opin. Chem. Biol. 200711, 644-653.

 

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48. 

A Continuous Fluorometric Assay for the Assessment of MazF Ribonuclease Activity 

Wang, N. R.; Hergenrother, P. J. 

Anal. Biochem. 2007371, 173-183.

 

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47. 

Increased Poly(ADP-ribose) Polymerase Activity During Porcine Hemorrhagic Shock is Transient and Predictive of Mortality 

Skarda, D. E.; Putt, K. S.; Hergenrother, P. J.; Mulier, K. E.; Beilman, G. J. 

Resuscitation 200775, 135-144.

 

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46. 

Multiplex Targeting, Tracking and Imaging of Apoptosis by Fluorescent Surface Enhanced Raman Spectroscopic Dots 

Yu, K. N.; Lee, S.-M.; Han, J. Y.; Park, H.; Woo, M.-A.; Noh, M. S.; Hwang, S.-K.; Kwon, J.-T.; Jin, H.; Kim, Y.-K.; Hergenrother, P. J.; Jeong, D. H.; Lee, Y.-S.; Cho, M.-H. 

Bioconjugate Chem. 200718, 1155-1162.

 

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45. 

A Novel Colorimetric Substrate for Poly(ADP-Ribose) Polymerase-1 (PARP-1), VPARP, and Tankyrase-1

Nottbohm, A. C.; Dothager, R. S.; Putt, K. S.; Hoyt, M. T.; Hergenrother, P. J.  

Angew. Chem. Int. Ed. 200746, 2066-2069.

 

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44. 

The Promises and Pitfalls of Small-Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)

Nottbohm, A. C.; Hergenrother, P. J. 

Drug Discovery Research: New Frontiers in the Post-Genomic Era 2007, 163-185.

 

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43.

A Novel Synthetic Analogue of a Constituent of Isodon excisus Inhibits Transcription of CYP1A1, -1A2, and -1B1 by Preventing Activation of the Aryl Hydrocarbon Receptor

Sienkiewicz, P.; Ciolino, H.; Leslie, B. J.; Hergenrother, P. J.; Singletary, K.; Yeh, G. C.

Carcinogenesis 200728, 1052-1057.

 

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42. 

Toxin-Antitoxin System are Ubiquitous and Plasmid-Encoded in Vancomycin Resistant Enterococci (VRE) 

Moritz, E. M.; Hergenrother, P. J. 

Proc. Natl. Acad. Sci. 2007104, 311-316.

 

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41. 

The Prevalence of Plasmids and Other Mobile Genetic Elements in Clinically Important Drug-Resistant Bacteria 

Moritz, E. M.; Hergenrother, P. J. 

Antimicrobial Resistance in Bacteria 2007, 25-53.

 

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40. 

Small-Molecule Activation of Procaspase-3 to Caspase-3 as a Personalized Anticancer Strategy

Putt, K. S.; Chen, G. W.; Pearson, J. M.; Sandhorst, J. S.; Hoagland, M. S.; Kwon, J.-T.; Hwang, S.-K.; Jin, H.; Churchwell, M. I.; Cho, M.-H.; Doerge, D. R.; Helferich, W. G.; Hergenrother, P. J.  

Nat. Chem. Biol. 20062, 543-50.

 

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BBC News Highlight - #1 Most emailed story on website worldwide on Monday, August 28, 3:20 pm

Scientific American Highlight

Guardian Highlight

Nature Podcast - September 7, 2006; description of our work starts ~19 minutes in 

Nature Chemical Biology News Highlight

Nature Reviews Research Highlight

Chemical & Engineering News Highlight

39. 

The Compound 13-D Selectively Induces Apoptosis in White Blood Cancers Versus Other Cancer Cell Types

Putt, K. S.; Nesterenko, V.; Dothager, R. S.; Hergenrother, P. J.  

ChemBioChem 20067, 1916-1922.

 

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38. 

Biochemical and Thermodynamic Characterization of Compounds that Bind to RNA Hairpin Loops: Toward an Understanding of Selectivity 

Thomas, J. R.; Liu, X.; Hergenrother, P. J. 

Biochemistry 200645, 10928-10938. 

 

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37. 

Chemical Countermeasures for the Control of Bacterial Biofilms: Effective Compounds and Promising Targets 

Musk, D. J.; Hergenrother, P. J. 

Curr. Med. Chem. 200613, 2163-2177 (review).

 

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36. 

Obtaining and screening compound collections: A user’s guide and a call to chemists

Hergenrother, P. J.  

Curr. Opin. Chem. Biol. 200610, 213-218.

 

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35. 

Tools for Molecular Diversification and Their Applications to Chemical Biology

Silverman, S. K.; Hergenrother, P. J. 

Curr. Opin. Chem. Biol. 200610, 185-187.

 

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34. 

DNA Binders and Related Subjects. Topics in Current Chemistry 253 (Book Review) 

Hergenrother, P. J. 

J. Am. Chem. Soc. 2006128, 3469-3470.

 

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33. 

Size-Specific Ligands for RNA Hairpin Loops

Thomas, J. R.; Liu, X.; Hergenrother, P. J. 

J. Am. Chem. Soc. 2005127, 12434-12435. 

 

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32. 

Using Peptidic Inhibitors to Systematically Probe the S1' Site of Caspase-3 and Caspase-7

Goode, D. R.; Sharma, A. K.; Hergenrother, P. J. 

Org. Lett. 20057, 3529-3532.

 

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31. 

Iron Salts Perturb Biofilm Formation and Disrupt Existing Biofilms of Pseudomonas aeruginosa

Musk, D. J.; Banko, D. A.; Hergenrother, P. J.

Chem. Biol. 2005, 12, 789-796.

 

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Chemistry & Biology

Highlight

30. 

Synthesis and Identification of Small Molecules that Potently Induce Apoptosis in Melanoma Cell Through G1 Cell Cycle Arrest

Dothager, R. S.; Putt, K. S.; Allen, B. J.; Leslie, B. J.; Nesterenko, V.; Hergenrother, P. J. 

J. Am. Chem. Soc. 2005127, 8686-8696. 

 

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Chemical & Engineering

News Highlight

29. 

The Relationship Between Aminoglycosides' RNA Binding Proclivity and Their Antiplasmid Effect on an IncB Plasmid

Thomas, J. R.; DeNap, J. C. B.; Wong, M.; Hergenrother, P. J. 

Biochemistry 200544, 6800-6808. 

 

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28. 

Structure-based Design and In-Silico Virtual Screening of Combinatorial Libraries. A Combined Chemical/Computational Laboratory Assignment 

Baudry, J.; Hergenrother, P. J. 

J. Chem. Educ. 200582, 890-894.

 

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27. 

Bacterial Death comes Full Circle: Targeting Plasmid Replication in Drug-Resistant Bacteria 

DeNap, J. C. B.; Hergenrother, P. J. 

Org. Biomol. Chem. 20053, 959-966.

 

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26. 

Direct Quantitation of Poly(ADP-Ribose) Polymerase (PARP) Activity as a Method to Distinguish Necrotic and Apoptotic Death in Cell and Tissue Samples

Putt, K. S.; Beilman, G. J.; Hergenrother, P. J.

ChemBioChem 20056, 53-55. 

 

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25. 

Combating Drug-Resistant Bacteria: Small Molecule Mimics of Plasmid Incompatibility as Antiplasmid Compounds

DeNap, J. B.; Thomas, J. R.; Musk, D. J.; Hergenrother, P. J. 

J. Am. Chem. Soc. 2004126, 15402-15404. 

 

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UIUC News Highlight

Chemical & Engineering News Highlight

Outsourcing-Pharma News Highlight

Drug Discovery Today Highlight

24. 

Deoxystreptamine Dimers bind to RNA Hairpin Loops

Liu, X.; Thomas, J. R.; Hergenrother, P. J.  

J. Am. Chem. Soc. 2004126, 9196-9197. 

 

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23. 

Medicinal Chemistry - An Introduction 

Hergenrother, P. J. 

Synthesis 200413, 2248.

 

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22. 

A non-radiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): Application to inhibitor identification and evaluation

Putt, K. S.; Hergenrother, P. J. 

Anal. Biochem. 2004333, 256-264. 

 

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21. 

An Enzymatic Assay for Poly(ADP-Ribose) Polymerase (PARP-1) via the Chemical Quantitation of NAD+: Application to the High-Throughput Screening of Small Molecules as Potential Inhibitors

Putt, K. S.; Hergenrother, P. J. 

Anal. Biochem. 2004326, 78-86. 

 

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20. 

Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells

Nesterenko, V.; Putt, K. S.; Hergenrother, P. J.  

J. Am. Chem. Soc. 2003125, 14672-14673. 

 

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Chemical & Engineering

News Highlight 

19. 

Efficient Synthesis of Enantiopure β-Amino-γ-Keto Acids from ʟ-Homoserine

Sharma, A. K.; Hergenrother, P. J. 

Org. Lett. 20035, 2107-2109.

 

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18. 

The Use of pH to Influence Regio- and Chemoselectivity in the Asymmetric Aminohydroxylation of Styrenes 

Nesterenko, V.; Byers, J. T.; Hergenrother, P. J. 

Org. Lett. 20035, 281-284.

 

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FROM HARVARD

 

17. 

Dissecting Glucose Signaling with Diversity-Oriented Synthesis and Small Molecule Microarrays 

Kuruvilla, F. G.; Shamji, A. F.; Sternson, S. M.; Hergenrother, P. J.; Schreiber, S. L. 

Nature 2002416, 653-657.

 

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16. 

Small-Molecule Microarrays: Covalent Attachment and Screening of Alcohol Containing Small Molecules on Glass Slides

Hergenrother, P. J.; Depew, K. M.; Schreiber, S. L.  

J. Am. Chem. Soc. 2000122, 7849-7850.

 

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FROM TEXAS

 

15. 

Total Synthesis of Erythromycin B 

Breton, P.; Hergenrother, P. J.; Hida, T.; Hodgson, A.; Judd, A. S.; Kraynack, E.; Kym, P. R.; Lee, W.-C.; Loft, M. S.; Yamashita, M.; Martin, S. F. 

Tetrahedron 200763, 5709-5729.

 

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14. 

An Abiotic Strategy for the Enantioselective Synthesis of Erythromycin B

Hergenrother, P. J.; Hodgson, A.; Judd, A. S.; Lee, W.-C.; Martin, S. F.  

Angew. Chem. Int. Ed. 200342, 3278-3281.

 

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13. 

Altering Substrate Specificity of Phosphatidylcholine-Preferring Phospholipase C of Bacillus cereus by Random Mutagenesis of the Headgroup Binding Site 

Antikainen, N. M.; Hergenrother, P. J.; Harris, M. M.; Corbett, B.; Martin, S. F.

Biochemistry 200342, 1603-1610.

 

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12. 

Characterization of Erythromycin Analogs by Collisional Activated Dissociation and Infrared Multiphoton Dissociation in a Quadrupole Ion Trap 

Crowe, M. C.; Brodbelt, J. S.; Goolsby, B. J.; Hergenrother, P. J. 

J. Am. Soc. Mass. Spectrom. 200213, 630-649.

 

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11. 

Phosphatidylcholine-Preferring Phospholipase C from B. cereus. Function, Structure, and Mechanism.

Hergenrother, P. J.; Martin, S. F.  

Top. Curr. Chem. 2000211, 131-167.

 

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10. 

A Novel Class of Zinc Binding Inhibitors for the Phosphatidylcholine-Preferring Phospholipase C from Bacillus cereus

Martin, S. F.; Follows, B. C.; Hergenrother, P. J.; Franklin, C. L.  

J. Org. Chem. 200065, 4509-4514.

 

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9. 

The Choline Binding site of Phospholipase C (Bacillus cereus): Insights into Substrate Specificity 

Martin, S. F.; Follows, B. C.; Hergenrother, P. J.; Trotter, B. K. 

Biochemistry 200039, 3410-3415.

 

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8. 

Determination of the Substrate Specificity of the Phospholipase D from Streptomyces chromofuscus via an Inorganic Phosphate Quantitation Assay 

Martin, S. F.; DeBlanc, R. L.; Hergenrother, P. J. 

Anal. Biochem. 2000278, 106-110.

 

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7. 

Catalytic Cycle of the Phosphatidylcholine-Preferring Phospholipase C from Bacillus cereus. Solvent Viscosity, Deuterium Isotope Effects, and Proton Inventory Studies

Martin, S. F., Hergenrother, P. J. 

Biochemistry 199938, 4403-4408.

 

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6. 

General Base Catalysis by the Phosphatidylchloine-Preferring Phospholipase C from Bacillus cereus: the Role of Glu4 and Asp55

Martin, S. F.; Hergenrother, P. J. 

Biochemistry 199837, 5755-5760.

 

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5. 

Enzymatic Synthesis of a Modified Phospholipid and its Evaluation as a Substrate for B. cereus Phospholipase C 

Martin, S. F.; Hergenrother, P. J. 

Bioorg. Med. Chem. Lett. 19988, 593-596.

 

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4. 

Determination of the Kinetic Parameters for Phospholipase C (Bacillus cereus) on Different Phospholipid Substrates Using a Chromogenic Assay Based on the Quantitation of Inorganic Phosphate

Hergenrother, P. J.; Martin, S. F. 

Anal. Biochem. 1997251, 45-49.

 

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3. 

Chromogenic Assay for Phospholipase D from Streptomyces chromofuscus: Application to the Evaluation of Substrate Analogues

Hergenrother, P. J.; Martin, S. F.; Haas, M. K.  

Lipids 199732, 783-788.

 

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2. 

Expression and Site-Directed Mutagenesis of the Phosphatidylcholine-Preferring Phospholipase C from Bacillus cereus: Probing the Role of Active Site Glu146

Martin, S. F.; Spaller, M. R.; Hergenrother, P. J. 

Biochemistry 199635, 12970-12977.

 

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1. 

Chromogenic Assay for Phospholipase C from Bacillus cereus 

Hergenrother, P. J.; Spaller, M. R.; Haas, M. K.; Martin, S. F. 

Anal. Biochem. 1995229, 313-316.

 

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147.

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

Janin M.; Ortiz-Barahona V.; Boudreau M.W.; Hergenrother P.J.; Esteller M. and others

Acta Neuropathol2019, published on web August 19, 2019

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Professor Paul J. Hergenrother

hergenro@illinois.edu

261 Roger Adams Lab

600 S. Mathews Avenue

Urbana, IL 61802

The Chemistry Department at the University of Illinois

Copyright © 2014 The Hergenrother Group

Kate Neef

Administrative Assistant

kneef1@illinois.edu

245 Roger Adams Lab

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